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Continuous IV infusion of MESNA can prevent hemorrhagic cystitis in HSCT and retain MESNA concentration in urine.

作者信息

Jiang Q, Huang H, Liu Q, Sun J, Zhou H, Fan Z, Zhang Y, Huang F, Chai Y, Xu D, Lu Y, Wei Q, Yu G, Li X, Dai M, Xu N, Zhou D, Zhao H, Shen K, Mai Q, Zhou Y, Meng F

机构信息

Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

First Clinical Hospital, Southern Medical University, Guangzhou, China.

出版信息

Bone Marrow Transplant. 2015 Nov;50(11):1490-2. doi: 10.1038/bmt.2015.197. Epub 2015 Sep 14.

DOI:10.1038/bmt.2015.197
PMID:26367223
Abstract
摘要

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1
Continuous IV infusion of MESNA can prevent hemorrhagic cystitis in HSCT and retain MESNA concentration in urine.持续静脉输注美司钠可预防造血干细胞移植中的出血性膀胱炎，并维持尿液中美司钠的浓度。
Bone Marrow Transplant. 2015 Nov;50(11):1490-2. doi: 10.1038/bmt.2015.197. Epub 2015 Sep 14.
2
[Clinical investigation of acute hemorrhagic cystitis in hematopoietic stem cell transplantation prevented by continuous intravenous Mesna injection].[持续静脉注射美司钠预防造血干细胞移植中急性出血性膀胱炎的临床研究]
Zhonghua Xue Ye Xue Za Zhi. 2013 Feb;34(2):171-3.
3
[The prevention of hemorrhagic cystitis during the performance of bone marrow and peripheral blood stem cell transplantation in the hematologic cancer clinic].[血液肿瘤诊所进行骨髓和外周血干细胞移植期间出血性膀胱炎的预防]
Ter Arkh. 1996;68(10):49-52.
4
Impact of extended infusional mesna prophylaxis on the incidence of BK viruria and hemorrhagic cystitis following post-transplantation cyclophosphamide and CTLA4Ig-based haploidentical transplantation.移植后环磷酰胺和 CTLA4Ig 为基础的单倍体相合移植后，延长美司钠输注预防对 BK 病毒尿症和出血性膀胱炎发生率的影响。
Ann Hematol. 2020 Apr;99(4):839-845. doi: 10.1007/s00277-020-03930-w. Epub 2020 Feb 5.
5
[Risk factors and treatment of hemorrhagic cystitis in children after hematopoietic stem cell transplantation].[造血干细胞移植后儿童出血性膀胱炎的危险因素及治疗]
Zhonghua Er Ke Za Zhi. 2006 Feb;44(2):126-30.
6
Hemorrhagic Cystitis after Haploidentical Transplantation with Post-Transplantation Cyclophosphamide: Protective Effect of MESNA Continuous Infusion.异基因造血干细胞移植后应用环磷酰胺：美司钠持续输注的保护作用
Biol Blood Marrow Transplant. 2020 Aug;26(8):1492-1496. doi: 10.1016/j.bbmt.2020.04.028. Epub 2020 May 15.
7
Hemorrhagic cystitis complicating bone marrow transplantation.骨髓移植并发出血性膀胱炎。
Mayo Clin Proc. 1992 Feb;67(2):128-30. doi: 10.1016/s0025-6196(12)61312-3.
8
Cyclophosphamide-induced hemorrhagic cystitis in young patients with solid tumors: A single institution study.环磷酰胺诱导实体瘤年轻患者出血性膀胱炎：一项单机构研究。
Asia Pac J Clin Oncol. 2018 Oct;14(5):e460-e464. doi: 10.1111/ajco.13048. Epub 2018 Jul 10.
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[Evaluation of the benefits of sodium 2-mercaptoethane sulfonate (MESNA) therapy for children undergoing high-dose chemotherapy].[对接受大剂量化疗的儿童使用2-巯基乙烷磺酸钠（美司钠）治疗的获益评估]
Rinsho Ketsueki. 1993 Jan;34(1):7-12.
10
Mesna versus hyperhydration for the prevention of cyclophosphamide-induced hemorrhagic cystitis in bone marrow transplantation.美司钠与水化疗法预防骨髓移植中环磷酰胺所致出血性膀胱炎的比较
J Clin Oncol. 1991 Nov;9(11):2016-20. doi: 10.1200/JCO.1991.9.11.2016.

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Role of Natural Antioxidants in Cancer.天然抗氧化剂在癌症中的作用。
Cancer Treat Res. 2024;191:95-117. doi: 10.1007/978-3-031-55622-7_4.
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Canadian Urological Association Best Practice Report: Pediatric hemorrhagic cystitis.加拿大泌尿外科协会最佳实践报告：小儿出血性膀胱炎
Can Urol Assoc J. 2019 Nov;13(11):E325-E334. doi: 10.5489/cuaj.5993.

本文引用的文献

1
Full myeloablative conditioning and an unrelated HLA mismatched donor increase the risk for BK virus-positive hemorrhagic cystitis in allogeneic hematopoetic stem cell transplanted patients.清髓性预处理和非亲缘 HLA 不合供者增加异基因造血干细胞移植患者 BK 病毒阳性出血性膀胱炎的风险。
Anticancer Res. 2011 Mar;31(3):939-44.
2
Blood, and not urine, BK viral load predicts renal outcome in children with hemorrhagic cystitis following hematopoietic stem cell transplantation.血液，而非尿液，BK 病毒载量可预测造血干细胞移植后发生出血性膀胱炎的儿童的肾脏结局。
Biol Blood Marrow Transplant. 2011 Oct;17(10):1512-9. doi: 10.1016/j.bbmt.2011.02.012. Epub 2011 Mar 6.
3
Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplants is the complex result of BK virus infection, preparative regimen intensity and donor type.
异基因造血干细胞移植后发生出血性膀胱炎是 BK 病毒感染、预处理方案强度和供者类型等多种因素复杂作用的结果。
Haematologica. 2010 Jul;95(7):1183-90. doi: 10.3324/haematol.2009.016758. Epub 2010 Apr 21.
4
Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation.环磷酰胺和异环磷酰胺诱导出血性膀胱炎的病理生理学方面；活性氧和氮物种以及PARP激活的影响。
Cell Biol Toxicol. 2007 Sep;23(5):303-12. doi: 10.1007/s10565-006-0078-0. Epub 2007 Jan 15.
5
Histological changes in bladders of patients submitted to ifosfamide chemotherapy even with mesna prophylaxis.接受异环磷酰胺化疗（即使使用美司钠预防）的患者膀胱的组织学变化。
Cancer Chemother Pharmacol. 2007 Apr;59(5):643-50. doi: 10.1007/s00280-006-0307-5. Epub 2006 Sep 1.
6
The incidence of hemorrhagic cystitis and BK-viruria in allogeneic hematopoietic stem cell recipients according to intensity of the conditioning regimen.根据预处理方案强度，异基因造血干细胞移植受者出血性膀胱炎和BK病毒尿的发生率。
Haematologica. 2006 Mar;91(3):401-4.
7
[Mismatched hematopoietic stem cell transplantation using GIAC protocol: report of 100 cases].采用GIAC方案的错配造血干细胞移植：100例报告
Zhonghua Xue Ye Xue Za Zhi. 2004 Aug;25(8):453-7.
8
Monitoring of urinary acrolein concentration in patients receiving cyclophosphamide and ifosphamide.对接受环磷酰胺和异环磷酰胺治疗的患者尿中丙烯醛浓度的监测。
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jun 25;806(1):59-63. doi: 10.1016/j.jchromb.2004.02.008.
9
Inactivation of acrolein by sodium 2-mercaptoethanesulfonate using headspace-solid-phase microextraction gas chromatography and mass spectrometry.使用顶空-固相微萃取气相色谱-质谱联用技术研究2-巯基乙烷磺酸钠对丙烯醛的灭活作用
J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 5;791(1-2):365-9. doi: 10.1016/s1570-0232(03)00259-9.
10
A new regimen of MESNA (2-mercaptoethanesulfonate) effectively prevents cyclophosphamide-induced hemorrhagic cystitis in bone marrow transplant recipients.一种新的美司钠（2-巯基乙烷磺酸盐）治疗方案能有效预防骨髓移植受者环磷酰胺诱导的出血性膀胱炎。
Transplant Proc. 2000 May;32(3):596. doi: 10.1016/s0041-1345(00)00906-4.