Murphy G M, Dowd P M, Hudspith B N, Brostoff J, Greaves M W
Institute of Dermatology, St Thomas' Hospital, London, United Kingdom.
Photodermatol. 1989 Dec;6(6):268-74.
Using an in vivo skin chamber method, we demonstrated increased release of interleukin-1 (IL-1)-like activity at the site of irradiation with 3 times the minimal erythema dose of ultraviolet B (UVB). IL-1-like activity was estimated using the mouse thymocyte amplification assay. UVB-augmented release of IL-1-like activity peaked 1 h after irradiation and levels returned to baseline by 2 h. Release of IL-1-like activity from human skin after exposure to UV radiation may account for some of the local and systemic features of the sunburn response.
使用体内皮肤腔室法，我们证明，在用三倍于紫外线B（UVB）最小红斑量进行照射的部位，白细胞介素-1（IL-1）样活性的释放增加。使用小鼠胸腺细胞增殖试验来评估IL-1样活性。UVB增强的IL-1样活性释放在照射后1小时达到峰值，2小时后水平恢复到基线。暴露于紫外线辐射后人皮肤中IL-1样活性的释放可能是晒伤反应的一些局部和全身特征的原因。
