Granstein R D, Sauder D N
Lymphokine Res. 1987 Summer;6(3):187-93.
Human volunteers given one minimal erythemal dose of ultraviolet radiation (UVR) from fluorescent sunlamps developed increased serum interleukin-1 (IL-1) activity as assessed by the thymocyte co-stimulator assay. This activity peaked 1 to 4 hours after exposure and returned to baseline by 8 hours after exposure. Six to 12 months later, some of the same subjects had blood samples taken over the same time course but without exposure to UVR; no elevation in serum IL-1 was observed. In addition to lymphocyte activating activity, IL-1 has been reported to have endogenous pyrogen activity, chemotactic activity for neutrophils and mononuclear cells, and inflammatory activity when injected subcutaneously in vivo. Elevations in serum IL-1 activity after exposure to ultraviolet radiation may account for some of the manifestations of the sunburn response.
通过荧光太阳灯给予人类志愿者一个最小红斑量的紫外线辐射（UVR）后，采用胸腺细胞共刺激试验评估发现，血清白细胞介素-1（IL-1）活性增加。该活性在暴露后1至4小时达到峰值，并在暴露后8小时恢复至基线水平。6至12个月后，部分相同受试者在相同时间进程内采集血样，但未暴露于UVR；未观察到血清IL-1升高。除淋巴细胞激活活性外，据报道IL-1还具有内源性致热活性、对中性粒细胞和单核细胞的趋化活性以及在体内皮下注射时的炎症活性。暴露于紫外线辐射后血清IL-1活性升高可能是晒伤反应某些表现的原因。
