Dabrowski M, Grzelak I, Ruzyłło V, Lukomska B, Sadowska-Szablisty D, Olszewski W L
Department of Cardiology, Polish Academy of Sciences, Warsaw.
Cor Vasa. 1989;31(6):476-84.
Cell-mediated immune responsiveness was evaluated in 8 patients with dilated cardiomyopathy (CDM). The percentage of blood OKM1 (monocytes), OKT3 (T-cells), OKT4 (helper cells), OKT8 (suppressor cells) and Leu7 (NK) positive cells remained within the normal range whereas the percentage of Leu11 (NK) and OKIa1 (Ia determinant) positive cells was found decreased. The NK cell cytotoxicity was significantly lowered. The ConA-suppressor cell activity was found increased while the responsiveness of lymphocytes to ConA decreased. Taken together, no consistent numerical changes in lymphocyte subsets were observed in patients with CDM, however, some functional deficiencies which may play a role in the pathogenesis of CDM were detected.
对8例扩张型心肌病（CDM）患者的细胞介导免疫反应性进行了评估。血液中OKM1（单核细胞）、OKT3（T细胞）、OKT4（辅助细胞）、OKT8（抑制细胞）和Leu7（自然杀伤细胞）阳性细胞的百分比保持在正常范围内，而Leu11（自然杀伤细胞）和OKIa1（Ia决定簇）阳性细胞的百分比则降低。自然杀伤细胞的细胞毒性显著降低。发现刀豆蛋白A抑制细胞活性增加，而淋巴细胞对刀豆蛋白A的反应性降低。综上所述，CDM患者未观察到淋巴细胞亚群一致的数值变化，然而，检测到一些可能在CDM发病机制中起作用的功能缺陷。
