Chumburidze V B, Iurenev A P, Tabazari D Z, Dzidziguri L M, Krukovskaia Z V
Ter Arkh. 1986;58(10):59-62.
Forty patients with dilatation cardiomyopathy (DCM) and 30 patients with hypertrophic cardiomyopathy (HCM) were examined immunologically. Immunoregulatory lymphocytes (T1B) and their subpopulations (T helpers, T suppressors, natural killers--NK) were studied quantitatively and functionally. The patients with DCM showed inhibition of the number of T suppressors in part of the cases, attended by a decrease in non-specific (spontaneous) and mitogenin-induced suppressor activity, the lowering of the amount and activity of NK in the overwhelming majority of the cases. Study of the immunological characteristics in the patients with HCM did not reveal any substantial changes as compared to those in health. Immune disorders in the patients with DCM form the basis for conducting goal-oriented immunocorrection.
对40例扩张型心肌病（DCM）患者和30例肥厚型心肌病（HCM）患者进行了免疫学检查。对免疫调节淋巴细胞（T1B）及其亚群（辅助性T细胞、抑制性T细胞、自然杀伤细胞——NK）进行了定量和功能研究。部分DCM患者显示抑制性T细胞数量减少，同时非特异性（自发）和丝裂原诱导的抑制活性降低，绝大多数病例中NK细胞数量和活性降低。与健康人相比，对HCM患者的免疫学特征研究未发现任何实质性变化。DCM患者的免疫紊乱构成了进行针对性免疫纠正的基础。
