Fiocca R, Villani L, De Giacomo C, Perego M, Trespi E, Solcia E
Acta Gastroenterol Belg. 1989 May-Aug;52(3-4):324-35.
Campylobacter pylori (CP) were found in 84% of 384 patients with chronic gastritis and in none of 49 subjects without inflammation. CP were present in similar percentages among patients with active (90%) or healed peptic ulcer (84%), as well as in non-ulcerous dyspepsia complicated by gastritis (91%). Cytoplasmic vacuolization and swelling of foveolar-superficial cells with adhering bacteria, micropapillae and microerosions were commonly found in CP-infected mucosa. In 100 cases with gastritis both intraepithelial granulocytes and epithelial lesions were prominent features of heavily CP-infected antral mucosa. The occurrence of some cases with abundant, adhering CP but lacking epithelial lesions is in keeping with the different ability of various CP-strains to produce cytotoxins. In 16 of 19 children with type B chronic gastritis antibacterial therapy eradicated CP. This was followed by resolution or striking improvement of gastritis and disappearance of epithelial lesions. These data provide further morphological evidence of direct cytotoxic activity of CP toward gastric mucosal cells.
在384例慢性胃炎患者中，84%检测出幽门螺杆菌（CP），而49例无炎症的受试者中均未检测到。在活动性消化性溃疡患者（90%）或愈合性消化性溃疡患者（84%）以及合并胃炎的非溃疡性消化不良患者（91%）中，CP的检出率相似。在CP感染的黏膜中，常见胞质空泡化以及伴有黏附细菌的小凹浅表细胞肿胀、微乳头和微糜烂。在100例胃炎病例中，上皮内粒细胞和上皮病变是CP重度感染胃窦黏膜的突出特征。一些病例中CP大量黏附但缺乏上皮病变，这与不同CP菌株产生细胞毒素的能力不同有关。在19例B型慢性胃炎儿童中，16例经抗菌治疗根除了CP。随后胃炎消退或显著改善，上皮病变消失。这些数据为CP对胃黏膜细胞的直接细胞毒活性提供了进一步的形态学证据。
