中欧家猫中γ疱疹病毒感染的患病率及危险因素
Prevalence and risk factors of gammaherpesvirus infection in domestic cats in Central Europe.
作者信息
Ertl Reinhard, Korb Melanie, Langbein-Detsch Ines, Klein Dieter
机构信息
VetCore Facility for Research, University of Veterinary Medicine Vienna, Vienna, Austria.
Laboklin GmbH & Co KG, Bad Kissingen, Germany.
出版信息
Virol J. 2015 Sep 17;12:146. doi: 10.1186/s12985-015-0381-6.
BACKGROUND
Gammaherpesviruses (GHVs) are a large group of dsDNA viruses that can infect humans and several animal species. The two human GHVs, Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus are known for their oncogenic properties in individuals with immunodeficiency. Recently, the first feline GHV, Felis catus gammaherpesvirus 1 (FcaGHV1) was discovered and frequently found in domestic cats in Australia, Singapore and the USA. FcaGHV1 is more likely to be detected in cats co-infected with the feline immunodeficiency virus (FIV).
FINDINGS
The prevalence of FcaGHV1 in pet cats from Germany and Austria was 16.2 % (95 % CI = 12.38-20.02). The odds for GHV infection were greater for FIV positive (OR = 4.5), male (OR = 13.32) and older (OR = 2.36) cats. Furthermore, FcaGHV1 viral loads were significantly higher in FIV-infected cats compared to matched controls.
CONCLUSIONS
GHV infections are common in domestic cats in Central Europe. The worldwide distribution of FcaGHV1 can be assumed. A potential role as a co-factor in FIV-induced pathogeneses is supported.
背景
γ疱疹病毒（GHV）是一大类双链DNA病毒，可感染人类和多种动物。两种人类GHV，即爱泼斯坦-巴尔病毒和卡波西肉瘤相关疱疹病毒，以其在免疫缺陷个体中的致癌特性而闻名。最近，发现了首例猫γ疱疹病毒，即猫γ疱疹病毒1型（FcaGHV1），并在澳大利亚、新加坡和美国的家猫中频繁发现。FcaGHV1在与猫免疫缺陷病毒（FIV）共同感染的猫中更易被检测到。
研究结果
德国和奥地利宠物猫中FcaGHV1的流行率为16.2%（95%置信区间=12.38-20.02）。FIV阳性（比值比=4.5）、雄性（比值比=13.32）和年龄较大（比值比=2.36）的猫感染GHV的几率更高。此外，与配对对照组相比，FIV感染猫的FcaGHV1病毒载量显著更高。
结论
GHV感染在中欧家猫中很常见。可以推测FcaGHV1在全球范围内都有分布。支持其作为FIV诱导发病机制中的一个辅助因子的潜在作用。
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