Khalil H A, van Best J A, de Keizer R J
Department of Ophthalmology, Leiden University Hospital, The Netherlands.
Doc Ophthalmol. 1989 Nov;73(3):249-54. doi: 10.1007/BF00155094.
The function of the corneal epithelium was evaluated in 30 patients with Graves' ophthalmopathy in whom no signs of corneal disease were observed. This function was evaluated by determining the permeability values of the corneal epithelium for fluorescein using fluorophotometry. The permeability values of the patients were compared with those of 46 healthy individuals. A significant increase in the permeability values was seen in 11 (37%) patients and in two (4%) controls (p less than 0.05). The difference in the mean permeability values between patients en controls was statistically significant (0.053 nm/sec. +/- 0.043 SD and 0.038 nm/sec. +/- 0.017 SD, respectively, p less than 0.05). No relation was found between the permeability values of the corneal epithelium and the NOSPECS classification or the duration of the disease. There was a tendency for increased permeability values in patients having an exophthalmos larger than 20 mm. (correl. coeff. = + 0.3, p less than 0.05).
对30例无角膜疾病体征的格雷夫斯眼病患者的角膜上皮功能进行了评估。通过荧光光度法测定角膜上皮对荧光素的通透性值来评估该功能。将患者的通透性值与46名健康个体的通透性值进行比较。11例（37%）患者和2例（4%）对照者的通透性值显著升高（p<0.05）。患者与对照者的平均通透性值差异具有统计学意义（分别为0.053 nm/秒±0.043标准差和0.038 nm/秒±0.017标准差，p<0.05）。未发现角膜上皮通透性值与NOSPECS分级或疾病持续时间之间存在关联。眼球突出大于20 mm的患者有通透性值升高的趋势（相关系数=+0.3，p<0.05）。
