Boets E P, Kerkmeer M J, van Best J A
Department of Ophthalmology, University Hospital Leiden, The Netherlands.
Ophthalmic Res. 1994;26(3):129-36. doi: 10.1159/000267403.
The aim of the study was to evaluate the effect of residual concentrations of two contact lens care solutions (hydrogen peroxide and polyaminopropyl biguanide) on corneal barrier function in vivo. The barrier function was determined by fluorophotometric measurement of corneal epithelial permeability in 30 contact lens wearing healthy subjects after 1 month's use of each of the solutions. All participants except one had corneal epithelial permeability values within the range for non-contact lens wearing healthy volunteers (0.011-0.061 and 0.008-0.090 nm/s, respectively). The deviating value (0.14 nm/s) was due to improper use of the contact lens care system. No statistical significant difference between the permeability values after use of the two contact lens care solutions was found (Wilcoxon ranked paired test: p = 0.2). It can be concluded that both solutions do not have harmful effects on corneal epithelial barrier function, provided the handling instructions are followed.
该研究的目的是评估两种隐形眼镜护理液（过氧化氢和聚氨基丙基双胍）的残留浓度对体内角膜屏障功能的影响。通过荧光光度法测量30名佩戴隐形眼镜的健康受试者在使用每种护理液1个月后的角膜上皮通透性来确定屏障功能。除一名受试者外，所有参与者的角膜上皮通透性值均在未佩戴隐形眼镜的健康志愿者的范围内（分别为0.011 - 0.061和0.008 - 0.090 nm/s）。偏差值（0.14 nm/s）是由于隐形眼镜护理系统使用不当所致。使用两种隐形眼镜护理液后的通透性值之间未发现统计学上的显著差异（Wilcoxon秩和配对检验：p = 0.2）。可以得出结论，只要遵循操作说明，两种护理液对角膜上皮屏障功能均无有害影响。
