Samy Mamdouh Nabil, Hamed Ashraf Nageeb El-Sayed, Sugimoto Sachiko, Otsuka Hideaki, Kamel Mohamed Salah, Matsunami Katsuyoshi
a Department of Pharmacognosy, Graduate School of Biomedical & Health Sciences , Hiroshima University , Hiroshima , Japan.
b Faculty of Pharmacy, Department of Pharmacognosy , Minia University , Minia , Egypt.
Nat Prod Res. 2016;30(8):967-72. doi: 10.1080/14786419.2015.1088540. Epub 2015 Sep 18.
A new lignan glucoside, officinalioside (1), was isolated from n-BuOH fraction of the aerial parts of Borago officinalis L., together with four known compounds: actinidioionoside (2), roseoside (3), crotalionoside C (4) and kaempferol 3-O-β-D-galactopyranoside (5). The structure of the new compound was established by means of spectroscopic and chemical analyses. Compounds 1 and 2 showed a moderate DPPH radical scavenging activity (IC50: 52.6 ± 1.70 and 41.3 ± 0.25 μM, respectively) comparable with that of the standard trolox (16.6 ± 2.2 μM) without any significant cytotoxicity towards human cell line A549 (IC50 > 100 μM).
从琉璃苣地上部分的正丁醇萃取物中分离出一种新的木脂素苷，即药用苷（1），以及四种已知化合物：猕猴桃苷（2）、蔷薇苷（3）、猪屎豆苷C（4）和山柰酚3 - O - β - D - 吡喃半乳糖苷（5）。通过光谱和化学分析确定了新化合物的结构。化合物1和2表现出中等程度的DPPH自由基清除活性（IC50分别为52.6±1.70和41.3±0.25μM），与标准曲克芦丁（16.6±2.2μM）相当，且对人细胞系A549没有任何明显的细胞毒性（IC50>100μM）。
