加拿大成人重症监护病房患者流感的流行病学特征
Epidemiological features of influenza in Canadian adult intensive care unit patients.
作者信息
Taylor G, Abdesselam K, Pelude L, Fernandes R, Mitchell R, McGeer A, Frenette C, Suh K N, Wong A, Katz K, Wilkinson K, Mersereau T, Gravel D
机构信息
University of Alberta Hospital,Edmonton,Alberta,Canada.
Public Health Agency of Canada,Centre for Communicable Diseases and Infection Control,Ottawa,Ontario,Canada.
出版信息
Epidemiol Infect. 2016 Mar;144(4):741-50. doi: 10.1017/S0950268815002113. Epub 2015 Sep 18.
To identify predictive factors and mortality of patients with influenza admitted to intensive care units (ICU) we carried out a prospective cohort study of patients hospitalized with laboratory-confirmed influenza in adult ICUs in a network of Canadian hospitals between 2006 and 2012. There were 626 influenza-positive patients admitted to ICUs over the six influenza seasons, representing 17·9% of hospitalized influenza patients, 3·1/10,000 hospital admissions. Variability occurred in admission rate and proportion of hospital influenza patients who were admitted to ICUs (proportion range by year: 11·7-29·4%; 21·3% in the 2009-2010 pandemic). In logistic regression models ICU patients were younger during the pandemic and post-pandemic period, and more likely to be obese than hospital non-ICU patients. Influenza B accounted for 14·2% of all ICU cases and had a similar ICU admission rate as influenza A. Influenza-related mortality was 17·8% in ICU patients compared to 2·0% in non-ICU patients.
为了确定入住重症监护病房（ICU）的流感患者的预测因素和死亡率，我们对2006年至2012年间加拿大医院网络中成人ICU收治的实验室确诊流感患者进行了一项前瞻性队列研究。在六个流感季节中，共有626名流感阳性患者入住ICU，占住院流感患者的17.9%，每10000例住院患者中有3.1例。入住ICU的流感患者的入院率和比例存在差异（每年的比例范围：11.7%-29.4%；2009-2010年大流行期间为21.3%）。在逻辑回归模型中，ICU患者在大流行期间和大流行后年龄较小，且比非ICU住院患者更易肥胖。乙型流感占所有ICU病例的14.2%，其ICU入院率与甲型流感相似。ICU患者的流感相关死亡率为17.8%，而非ICU患者为2.0%。
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