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因急性细支气管炎住院的婴儿的病毒病因。

Viral etiology in infants hospitalized for acute bronchiolitis.

作者信息

Azkur Dilek, Özaydın Eda, Dibek-Mısırlıoğlu Emine, Vezir Emine, Tombuloğlu Duygu, Köse Gülşen, Kocabaş Can N

机构信息

Division of Pediatric Allergy and Immunology, Ankara Children's Hematology Oncology Training and Research Hospital, Ankara, Turkey.

出版信息

Turk J Pediatr. 2014 Nov-Dec;56(6):592-6.

Abstract

Acute bronchiolitis is predominantly a viral disease. Respiratory syncytial virus is the most common agent, but other newly identified viruses have also been considered as causes. The aim of the present study is to determine the respiratory viruses causing acute bronchiolitis in hospitalized infants. Infants younger than 2 years of age who were hospitalized for acute viral bronchiolitis in a children's hospital between November 2011 and May 2012 were evaluated for the presence of viruses as etiologic agents using a realtime polymerase chain reaction method.A total of 55 infants were included in this study. The mean age of the children was 6.98±5.53 months, and 63.6% were male. In the 55 children, 63 viruses were detected. A single viral pathogen was detected in 47 (85.5%) patients, and two viruses were co-detected in 8 (14.6%) patients. Respiratory syncytial virus was the most common virus identified, accounting for 25 (45.5%) cases, followed by rhinovirus (n=9, 16.4%), and human metapneumovirus (n = 8, 14.5%).Although respiratory syncytial virus remains the major viral pathogen in infants hospitalized for acute broncholitis, more than half of bronchiolitis cases are associated with other respiratory viruses.

摘要

急性细支气管炎主要是一种病毒性疾病。呼吸道合胞病毒是最常见的病原体,但其他新发现的病毒也被认为是病因。本研究的目的是确定导致住院婴儿急性细支气管炎的呼吸道病毒。对2011年11月至2012年5月期间在一家儿童医院因急性病毒性细支气管炎住院的2岁以下婴儿,使用实时聚合酶链反应方法评估是否存在作为病原体的病毒。本研究共纳入55名婴儿。儿童的平均年龄为6.98±5.53个月,63.6%为男性。在这55名儿童中,检测到63种病毒。47名(85.5%)患者检测到单一病毒病原体,8名(14.6%)患者同时检测到两种病毒。呼吸道合胞病毒是最常见的病毒,占25例(45.5%),其次是鼻病毒(9例,16.4%)和人偏肺病毒(8例,14.5%)。虽然呼吸道合胞病毒仍然是因急性细支气管炎住院婴儿的主要病毒病原体,但超过一半的细支气管炎病例与其他呼吸道病毒有关。

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