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参与脂肪分解的基因在超重和肥胖个体减肥计划中的作用。

The role of genes involved in lipolysis on weight loss program in overweight and obese individuals.

作者信息

Luglio Harry Freitag, Sulistyoningrum Dian Caturini, Susilowati Rina

机构信息

Department of Health Nutrition, Faculty of Medicine, Universitas Gadjah Mada, Jl. Farmako, Sekip Utara, Yogyakarta 55281, Indonesia.

Department of Histology and Cell Biology, Faculty of Medicine, Universitas Gadjah Mada, Jl. Farmako, Sekip Utara, Yogyakarta 55281, Indonesia.

出版信息

J Clin Biochem Nutr. 2015 Sep;57(2):91-7. doi: 10.3164/jcbn.14-117. Epub 2015 Aug 19.

DOI:10.3164/jcbn.14-117
PMID:26388665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4566022/
Abstract

The ability of obese people to reduce weight in the same treatment varied. Genetic make up as well as the behavioral changes are important for the successfulness of the program. One of the most proposed genetic variations that have been reported in many intervention studies was genes that control lipolysis process. This review summarizes studies that were done showing the influence of genetic polymorphisms in lipolysis pathway and weight loss in a weight loss treatment program. Some studies had shown that certain enzymes involved in this process were related to successfulness of weight loss program. Single Nucleotide Polymorphism (SNP) in PLIN (11482G>A) and ADRB3 (Trp64Arg) are the most studied polymorphisms that have effect on weight loss intervention. However, those studies were not conclusive because of limited number of subjects used and controversies in the results. Thus, replication and confirmation on the role of those genes in weight loss are important due to their potential to be used as predictors of the results of the program.

摘要

肥胖人群在相同治疗中减轻体重的能力各不相同。基因组成以及行为改变对该计划的成功至关重要。在许多干预研究中报道的最常被提及的基因变异之一是控制脂肪分解过程的基因。这篇综述总结了所开展的研究，这些研究表明了脂肪分解途径中的基因多态性以及减肥治疗计划中的体重减轻情况。一些研究表明，参与这一过程的某些酶与减肥计划的成功有关。PLIN（11482G>A）和ADRB3（Trp64Arg）中的单核苷酸多态性（SNP）是对减肥干预影响研究最多的多态性。然而，由于所使用的受试者数量有限以及结果存在争议，这些研究尚无定论。因此，鉴于这些基因有潜力用作该计划结果的预测指标，对其在减肥中的作用进行重复研究和确认很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ad/4566022/44236e31b90f/jcbn14-117f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ad/4566022/bf156139989e/jcbn14-117f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ad/4566022/44236e31b90f/jcbn14-117f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ad/4566022/bf156139989e/jcbn14-117f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ad/4566022/44236e31b90f/jcbn14-117f02.jpg

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