血液 perilipin A 水平对肥胖和代谢健康的影响。

Impact of blood perilipin A levels on obesity and metabolic health.

机构信息

Department of Chemical Pathology, University of Ghana Medical School, Accra, Ghana.

Department of Medical Pharmacology, University of Ghana Medical School, Accra, Ghana.

出版信息

BMC Res Notes. 2022 Dec 12;15(1):367. doi: 10.1186/s13104-022-06261-3.

DOI:10.1186/s13104-022-06261-3

PMID:36503541

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9743615/

Abstract

OBJECTIVE

Perilipin A is a common protein that coats lipid surfaces preventing them from being exposed to oxidative damage. Researchers have found little consistency in the relationship between perilipin A levels in the blood and body fat. This study was a cross-sectional observational that looked at circulating perilipin A levels and how they relate to metabolic health.

RESULTS

The participants in this study were 86 individuals with a mean age of 45.5 ± 1.2 years. Multiple clinical and metabolic indicators (age, weight, BMI, total body fat mass, triglyceride, and HOMA-IR) were shown to be inversely associated with perilipin A levels (rho = - 0.32, - 0.37, - 0.40, - 0.45, - 0.33 and - 0.29; p < 0.05 respectively). Obese persons were almost six times more likely than non-obese individuals to have lower perilipin A levels (odds ratio = 6.22, CI = 2.35-11.50, p < 0.001). Our findings underscore the important role of perilipin A proteins in metabolic health.

摘要

目的

脂滴包被蛋白 A 是一种常见的蛋白质，可防止脂质表面受到氧化损伤。研究人员发现，血液中脂滴包被蛋白 A 水平与体脂肪之间的关系缺乏一致性。本研究为横断面观察性研究，旨在研究循环脂滴包被蛋白 A 水平及其与代谢健康的关系。

结果

本研究的参与者为 86 名平均年龄为 45.5±1.2 岁的个体。多项临床和代谢指标（年龄、体重、BMI、全身脂肪量、甘油三酯和 HOMA-IR）与脂滴包被蛋白 A 水平呈负相关（rho=-0.32、-0.37、-0.40、-0.45、-0.33 和-0.29；p<0.05 分别）。肥胖者的脂滴包被蛋白 A 水平低于非肥胖者的可能性几乎高出六倍（比值比=6.22，CI=2.35-11.50，p<0.001）。我们的研究结果强调了脂滴包被蛋白 A 蛋白在代谢健康中的重要作用。