Huang Yi, Huang Yu, Chang Aoshuang, Wang Jishi, Zeng Xiaoqing, Wu Jiahong
Department of Hematology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China (mainland).
Department of Invasive Technology, Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, China (mainland).
Med Sci Monit. 2016 May 7;22:1547-52. doi: 10.12659/msm.897155.
BACKGROUND Possible associations of parasite infection with cancer risk have recently attracted much attention. Published studies concerning the association between Toxoplasma gondii (T. gondii) infection and leukemia risk have generated inconsistent results. In the present study, we aimed to address this topic by conducting a quantitative meta-analysis. MATERIAL AND METHODS Relevant publications were searched in electronic databases and eligible studies were rigorously screened and selected. Essential information was extracted and the data were pooled. Subgroup analysis on source of controls and detection target was also performed. RESULTS A total of 6 studies that met the inclusion criteria were selected. The overall data show that T. gondii infection might have an association with increased leukemia risk (OR=3.05; 95%CI=1.83-5.08). Similar results were shown in the subgroups regarding source of controls and detection target. CONCLUSIONS Our results suggest that T. gondii infection might be a risk factor for leukemia, providing new insight into the etiology of leukemia. Future studies with large sample sizes in different geographic areas are needed to confirm this conclusion.
背景 寄生虫感染与癌症风险之间可能存在的关联最近备受关注。已发表的关于弓形虫（T. gondii）感染与白血病风险之间关联的研究结果并不一致。在本研究中，我们旨在通过进行定量荟萃分析来探讨这一话题。
材料与方法 在电子数据库中检索相关出版物，并对符合条件的研究进行严格筛选和选择。提取基本信息并汇总数据。还对对照来源和检测目标进行了亚组分析。
结果 共选择了6项符合纳入标准的研究。总体数据表明，弓形虫感染可能与白血病风险增加有关（OR = 3.05；95%CI = 1.83 - 5.08）。在对照来源和检测目标的亚组中也显示出类似结果。
结论 我们的结果表明，弓形虫感染可能是白血病的一个风险因素，为白血病的病因学提供了新的见解。需要在不同地理区域进行大样本量的未来研究来证实这一结论。
