Cosgrove R F, Baines S
Antimicrob Agents Chemother. 1978 Mar;13(3):540-1. doi: 10.1128/AAC.13.3.540.
The in vitro activities of 5-chloro-8-hydroxyquinoline (CHQ) against single strains of 12 different species of mycoplasma and the impacts of repeated exposure of these strains to CHQ on their susceptibility to this agent have been studied. On initial exposure, the minimal inhibitory concentrations for these strains ranged from 0.24 to 1.92 micrograms of CHQ per ml of test medium; activities remained unchanged during 10 serial transfers in CHQ-containing medium.
研究了5-氯-8-羟基喹啉(CHQ)对12种不同支原体单一菌株的体外活性,以及这些菌株反复接触CHQ对其对该药物敏感性的影响。初次接触时,这些菌株的最低抑菌浓度范围为每毫升测试培养基含0.24至1.92微克CHQ;在含CHQ的培养基中连续传代10次期间,活性保持不变。