通过代谢工程提高生物强化水稻中叶酸（维生素 B9）的稳定性。
Improving folate (vitamin B9) stability in biofortified rice through metabolic engineering.
机构信息
Laboratory of Functional Plant Biology, Department of Physiology, Ghent University, Ghent, Belgium.
Laboratory of Toxicology, Department of Bioanalysis, Ghent University, Ghent, Belgium.
出版信息
Nat Biotechnol. 2015 Oct;33(10):1076-8. doi: 10.1038/nbt.3358. Epub 2015 Sep 21.
Biofortification of staple crops could help to alleviate micronutrient deficiencies in humans. We show that folates in stored rice grains are unstable, which reduces the potential benefits of folate biofortification. We obtain folate concentrations that are up to 150 fold higher than those of wild-type rice by complexing folate to folate-binding proteins to improve folate stability, thereby enabling long-term storage of biofortified high-folate rice grains.
生物强化主食作物可以帮助缓解人体的微量营养素缺乏。我们表明，储存的稻谷中的叶酸不稳定，这降低了叶酸生物强化的潜在益处。我们通过将叶酸与叶酸结合蛋白复合来提高叶酸的稳定性，从而获得比野生型水稻高 150 倍的叶酸浓度，从而能够长期储存生物强化的高叶酸稻谷。
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