Laboratory Medicine Department, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 164 Lanxi Road, Shanghai, 200062, People's Republic of China.
Virol J. 2022 Sep 12;19(1):146. doi: 10.1186/s12985-022-01879-y.
The evaluation of human papillomavirus (HPV) prevalence rate dynamics and genotype distribution could support the adoption of more targeted prevention and treatment of cervical cancer. We aimed to assess the infection status and genotype characteristics of HPV among gynecological outpatients in Shanghai, China.
Clinical specimens were collected from patients attending gynaecological department of the Putuo Hospital, Shanghai University of Traditional Chinese Medicine, between January 2015 and December 2019. The cervicovaginal infection of 17 high-risk genotypes and 10 low-risk genotypes were analyzed by Luminex-based multiple assays.
The overall HPV infection rate was 18.81% (95% CI 18.31-19.30%) in Shanghai city, with high-risk, low-risk and mixed high- and low-risk HPV prevalence being 11.65% (95% CI 11.24-12.06%), 4.19% (95% CI 3.94-4.44%) and 2.96% (95% CI 2.74-3.17%), respectively. The five most prevalent high-risk genotypes were HPV-52 (2.95%), HPV-16 (2.34%), HPV-58 (2.07%), HPV-53 (1.67%) and HPV-39 (1.36%). The most common low-risk genotype was HPV-61 (1.52%), followed by HPV-6 (1.29%) and HPV-81 (1.19%). Moreover, the coverage of HPV genotype by nonavalent vaccine was 10.42%, and non-vaccine-covered high-risk genotype was 7.70%. The 15-24 years age group demonstrated the highest HPV prevalence (43.14%), and significant differences were observed among different age groups (P < 0.001).
This study revealed the HPV prevalence and genotype distribution among women in Shanghai city, which could serve as guidance for HPV vaccination and preventative strategies against cervical cancer in this area.
评估人乳头瘤病毒（HPV）流行率动态和基因型分布可以为更有针对性的宫颈癌预防和治疗提供支持。本研究旨在评估中国上海妇科门诊患者的 HPV 感染状况和基因型特征。
2015 年 1 月至 2019 年 12 月期间，采集上海中医药大学附属普陀医院妇科就诊患者的宫颈阴道标本。采用基于 Luminex 的多重分析方法检测 17 种高危型和 10 种低危型 HPV 的感染情况。
上海市 HPV 总感染率为 18.81%（95%CI 18.31-19.30%），高危型、低危型和高低危混合感染的 HPV 流行率分别为 11.65%（95%CI 11.24-12.06%）、4.19%（95%CI 3.94-4.44%）和 2.96%（95%CI 2.74-3.17%）。最常见的 5 种高危型 HPV 分别为 HPV-52（2.95%）、HPV-16（2.34%）、HPV-58（2.07%）、HPV-53（1.67%）和 HPV-39（1.36%）。最常见的低危型 HPV 为 HPV-61（1.52%），其次为 HPV-6（1.29%）和 HPV-81（1.19%）。此外，九价疫苗涵盖的 HPV 基因型比例为 10.42%，非疫苗覆盖的高危型 HPV 基因型比例为 7.70%。15-24 岁年龄组 HPV 感染率最高（43.14%），不同年龄组之间存在显著差异（P<0.001）。
本研究揭示了上海市女性 HPV 的流行率和基因型分布情况，可为该地区 HPV 疫苗接种和宫颈癌预防策略提供指导。
