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在美国军队中实施创伤后应激障碍预防性基因组测序项目面临的挑战。

CHALLENGES FOR IMPLEMENTING A PTSD PREVENTIVE GENOMIC SEQUENCING PROGRAM IN THE U.S. MILITARY.

作者信息

Lázaro-Muñoz Gabriel, Juengst Eric T

机构信息

Center for Genomics and Society at the University of North Carolina School of Medicine. He received his Ph.D. in Neuroscience from New York University, his J.D. and Master of Bioethics from the University of Pennsylvania School of Law and Perelman School of Medicine, and his B.A. from the University of Puerto Rico.

UNC Center for Bioethics and Professor in the Department of Social Medicine and the Department of Genetics at the University of North Carolina, Chapel Hill. He received his B.S. in Biology from the University of the South in 1978, and his Ph.D. in Philosophy from Georgetown University in 1985.

出版信息

Case West Reserve J Int Law. 2015 Spring;47(1):87-113.

PMID:26401056
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4577019/
Abstract

There is growing interest in using the quickly developing field of genomics to contribute to military readiness and effectiveness. Specifically, influential military advisory panels have recommended that the U.S. military apply genomics to help treat, prevent, or minimize the risk for post-traumatic stress disorder (PTSD) among service members. This article highlights some important scientific, legal, and ethical challenges regarding the development and deployment of a preventive genomic sequencing (PGS) program to predict the risk of PTSD among military service members.

摘要

人们越来越关注利用快速发展的基因组学领域来提升军事准备状态和效能。具体而言,有影响力的军事顾问小组建议美国军方应用基因组学来帮助治疗、预防或降低军人创伤后应激障碍(PTSD)的风险。本文重点介绍了在开发和部署预防性基因组测序(PGS)项目以预测军人患PTSD风险方面所面临的一些重要科学、法律和伦理挑战。

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本文引用的文献

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Schizophrenia genetics comes of age.精神分裂症遗传学崭露头角。
Neuron. 2014 Aug 20;83(4):760-3. doi: 10.1016/j.neuron.2014.08.015.
2
Biological insights from 108 schizophrenia-associated genetic loci.108 个精神分裂症相关遗传位点的生物学见解。
Nature. 2014 Jul 24;511(7510):421-7. doi: 10.1038/nature13595. Epub 2014 Jul 22.
3
PTSD in the U.S. military, and the politics of prevalence.美国军队中的创伤后应激障碍以及患病率相关政治问题。
Soc Sci Med. 2014 Aug;115:1-9. doi: 10.1016/j.socscimed.2014.05.051. Epub 2014 Jun 2.
4
Genome-scale neurogenetics: methodology and meaning.全基因组神经遗传学:方法与意义。
Nat Neurosci. 2014 Jun;17(6):756-63. doi: 10.1038/nn.3716. Epub 2014 May 27.
5
Genetic association analysis of 300 genes identifies a risk haplotype in SLC18A2 for post-traumatic stress disorder in two independent samples.对300个基因进行的遗传关联分析在两个独立样本中确定了溶质载体家族18成员2(SLC18A2)中与创伤后应激障碍相关的一个风险单倍型。
Neuropsychopharmacology. 2014 Jul;39(8):1872-9. doi: 10.1038/npp.2014.34. Epub 2014 Feb 14.
6
Gene-environment interaction.基因-环境交互作用。
Annu Rev Psychol. 2014;65:41-70. doi: 10.1146/annurev-psych-010213-115100.
7
Genetic discrimination in employment is indefensible.就业中的基因歧视是站不住脚的。
Hastings Cent Rep. 2013 Nov-Dec;43(6):3-4. doi: 10.1002/hast.219.
8
From candidate genes to genome-wide association: the challenges and promise of posttraumatic stress disorder genetic studies.从候选基因到全基因组关联研究:创伤后应激障碍基因研究的挑战与前景
Biol Psychiatry. 2013 Nov 1;74(9):634-6. doi: 10.1016/j.biopsych.2013.08.022.
9
Genome-wide association study implicates a novel RNA gene, the lincRNA AC068718.1, as a risk factor for post-traumatic stress disorder in women.全基因组关联研究提示一个新的 RNA 基因 lincRNA AC068718.1 是女性创伤后应激障碍的风险因素。
Psychoneuroendocrinology. 2013 Dec;38(12):3029-38. doi: 10.1016/j.psyneuen.2013.08.014. Epub 2013 Sep 8.
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Why are Iraq and Afghanistan War veterans seeking PTSD disability compensation at unprecedented rates?为什么伊拉克和阿富汗战争老兵以空前的速度寻求创伤后应激障碍残疾赔偿?
J Anxiety Disord. 2013 Jun;27(5):520-6. doi: 10.1016/j.janxdis.2013.07.002. Epub 2013 Jul 26.