基于干扰素的疗法对慢性丙型肝炎患者剪切波速度的影响
Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C.
作者信息
Osakabe Keisuke, Ichino Naohiro, Nishikawa Toru, Sugiyama Hiroko, Kato Miho, Shibata Ai, Asada Wakana, Kawabe Naoto, Hashimoto Senju, Murao Michihito, Nakano Takuji, Shimazaki Hiroaki, Kan Toshiki, Nakaoka Kazunori, Takagawa Yuka, Ohki Masashi, Kurashita Takamitsu, Takamura Tomoki, Yoshioka Kentaro
机构信息
Keisuke Osakabe, Naohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Kutsukake, Toyoake, Aichi 470-1192, Japan.
出版信息
World J Gastroenterol. 2015 Sep 21;21(35):10215-23. doi: 10.3748/wjg.v21.i35.10215.
AIM
To evaluate the changes of shear-wave velocity (Vs) by acoustic radiation force impulse after treatment in chronic hepatitis C.
METHODS
Eighty-seven patients with chronic hepatitis C were consecutively treated with combinations of interferon (IFN) plus ribavirin (RBV). Vs value (m/s) was measured with acoustic radiation force impulse before treatment, at end of treatment (EOT), 1 year after EOT, and 2 years after EOT.
RESULTS
In patients with a sustained virological response (SVR) (n = 41), Vs significantly decreased at EOT [1.19 (1.07-1.37), P = 0.0004], 1 year after EOT [1.10 (1.00-1.22), P = 0.0001], and 2 years after EOT [1.05 (0.95-1.16), P < 0.0001] compared with baseline [1.27 (1.11-1.49)]. In patients with a relapse (n = 26), Vs did not significantly decrease at EOT [1.23 (1.12-1.55)], 1 year after EOT [1.20 (1.12-1.80)], and 2 years after EOT [1.41 (1.08-2.01)] compared with baseline [1.39 (1.15-1.57)]. In patients with a nonvirological response (n = 20), Vs did not significantly decrease at EOT [1.64 (1.43-2.06)], 1 year after EOT [1.66 (1.30-1.95)], and 2 years after EOT [1.61 (1.36-2.37)] compared with baseline [1.80 (1.54-2.01)]. Among genotype 1 patients, baseline Vs was significantly lower in SVR patients [1.28 (1.04-1.40)] than in non-SVR patients [1.56 (1.20-1.83)] (P = 0.0142).
CONCLUSION
Reduction of Vs values was shown in SVR patients after IFN-plus-RBV therapy by acoustic radiation force impulse.
目的
评估慢性丙型肝炎患者经治疗后声辐射力脉冲剪切波速度（Vs）的变化。
方法
87例慢性丙型肝炎患者连续接受干扰素（IFN）联合利巴韦林（RBV）治疗。在治疗前、治疗结束时（EOT）、EOT后1年和EOT后2年，采用声辐射力脉冲测量Vs值（m/s）。
结果
获得持续病毒学应答（SVR）的患者（n = 41），与基线水平[1.27（1.11 - 1.49）]相比，EOT时[1.19（1.07 - 1.37），P = 0.0004]、EOT后1年[1.10（1.00 - 1.22），P = 0.0001]及EOT后2年[1.05（0.95 - 1.16），P < 0.0001]时Vs显著降低。复发患者（n = 26），与基线水平[1.39（1.15 - 1.57）]相比，EOT时[1.23（1.12 - 1.55）]、EOT后1年[1.20（1.12 - 1.80）]及EOT后2年[1.41（1.08 - 2.01）]时Vs未显著降低。未获得病毒学应答的患者（n = 20），与基线水平[1.80（1.54 - 2.01）]相比，EOT时[1.64（1.43 - 2.06）]、EOT后1年[1.66（1.30 - 1.95）]及EOT后2年[1.61（1.36 - 2.37）]时Vs未显著降低。在基因1型患者中，SVR患者的基线Vs[1.28（1.04 - 1.40）]显著低于非SVR患者[1.56（1.20 - 1.83）]（P = 0.0142）。
结论
声辐射力脉冲显示，IFN联合RBV治疗后，SVR患者的Vs值降低。
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