Nishikawa Toru, Hashimoto Senju, Kawabe Naoto, Harata Masao, Nitta Yoshifumi, Murao Michihito, Nakano Takuji, Mizuno Yuko, Shimazaki Hiroaki, Kan Toshiki, Nakaoka Kazunori, Takagawa Yuka, Ohki Masashi, Ichino Naohiro, Osakabe Keisuke, Yoshioka Kentaro
Toru Nishikawa, Senju Hashimoto, Naoto Kawabe, Masao Harata, Yoshifumi Nitta, Michihito Murao, Takuji Nakano, Yuko Mizuno, Hiroaki Shimazaki, Toshiki Kan, Kazunori Nakaoka, Yuka Takagawa, Masashi Ohki, Kentaro Yoshioka, Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health University, Aichi 470-1192, Japan.
World J Gastroenterol. 2014 Feb 7;20(5):1289-97. doi: 10.3748/wjg.v20.i5.1289.
To investigate the factors other than fibrosis stage correlating with acoustic radiation force impulse (ARFI) elastograpy in chronic hepatitis C.
ARFI elastograpy was performed in 108 consecutive patients with chronic hepatitis C who underwent a liver biopsy. The proportion of fibrosis area in the biopsy specimens was measured by computer-assisted morphometric image analysis.
ARFI correlated significantly with fibrosis stage (β = 0.1865, P < 0.0001) and hyaluronic acid levels (β = 0.0008, P = 0.0039) in all patients by multiple regression analysis. Fibrosis area correlated significantly with ARFI by Spearman's rank correlation test but not by multiple regression analysis. ARFI correlated significantly with body mass index (BMI) (β = -0.0334, P = 0.0001) in F 0 or F 1, with γ-glutamyltranspeptidase levels (β = 0.0048, P = 0.0012) in F 2, and with fibrosis stage (β = 0.2921, P = 0.0044) and hyaluronic acid levels (β = 0.0012, P = 0.0025) in F 3 or F 4. The ARFI cutoff value was 1.28 m/s for F ≥ 2, 1.44 m/s for F ≥ 3, and 1.73 m/s for F 4.
ARFI correlated with fibrosis stage and hyaluronic acid but not with inflammation. ARFI was affected by BMI, γ-glutamyltranspeptidase, and hyaluronic acid in each fibrosis stage.
研究慢性丙型肝炎中除纤维化分期外与声辐射力脉冲（ARFI）弹性成像相关的因素。
对108例连续接受肝活检的慢性丙型肝炎患者进行ARFI弹性成像检查。通过计算机辅助形态计量图像分析测量活检标本中纤维化区域的比例。
通过多元回归分析，在所有患者中ARFI与纤维化分期（β = 0.1865，P < 0.0001）和透明质酸水平（β = 0.0008，P = 0.0039）显著相关。通过Spearman等级相关检验，纤维化面积与ARFI显著相关，但多元回归分析结果并非如此。在F0或F1期，ARFI与体重指数（BMI）显著相关（β = -0.0334，P = 0.0001）；在F2期，与γ-谷氨酰转肽酶水平显著相关（β = 0.0048，P = 0.0012）；在F3或F4期，与纤维化分期（β = 0.2921，P = 0.0044）和透明质酸水平（β = 0.0012，P = 0.0025）显著相关。F≥2时ARFI临界值为1.28 m/s，F≥3时为1.44 m/s，F4时为1.73 m/s。
ARFI与纤维化分期和透明质酸相关，但与炎症无关。在每个纤维化阶段，ARFI均受BMI、γ-谷氨酰转肽酶和透明质酸的影响。
