Davis Karen D, Bushnell M Catherine, Iannetti Gian Domenico, St Lawrence Keith, Coghill Robert
Institute of Medical Science and Department of Surgery, University of Toronto, Toronto, ON, M5T 2S8, Canada ; Division of Brain Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, Toronto, ON, M5T 2S8, Canada ; Joint Department of Medical Imaging, University Health Network, Toronto, ON, M5T 2S8, Canada.
Pain and Integrative Neuroscience Branch, Division of Intramural Research, National Center for Complementary and Integrative Health (NCCIH), National Institutes of Health, Bethesda, MD, 20892-1302, USA.
F1000Res. 2015 Jul 24;4:362. doi: 10.12688/f1000research.6833.1. eCollection 2015.
The search for a "pain centre" in the brain has long eluded neuroscientists. Although many regions of the brain have been shown to respond to painful stimuli, all of these regions also respond to other types of salient stimuli. In a recent paper, Segerdahl et al. (Nature Neuroscience, 2015) claims that the dorsal posterior insula (dpIns) is a pain-specific region based on the observation that the magnitude of regional cerebral blood flow (rCBF) fluctuations in the dpIns correlated with the magnitude of evoked pain. However, such a conclusion is, simply, not justified by the experimental evidence provided. Here we discuss three major factors that seriously question this claim.
长期以来，神经科学家一直未能在大脑中找到“疼痛中枢”。尽管大脑的许多区域已被证明对疼痛刺激有反应，但所有这些区域对其他类型的显著刺激也有反应。在最近的一篇论文中，塞格达尔等人（《自然神经科学》，2015年）声称，基于背侧后岛叶（dpIns）区域脑血流（rCBF）波动幅度与诱发疼痛幅度相关的观察结果，背侧后岛叶是一个疼痛特异性区域。然而，这样的结论根本没有得到所提供实验证据的支持。在这里，我们讨论严重质疑这一说法的三个主要因素。
