Jaccob Ausama Ayoob
Department of Pharmacology and Toxicology, College of Pharmacy, University of Basra, Basra, Iraq.
J Intercult Ethnopharmacol. 2015 Apr-Jun;4(2):90-5. doi: 10.5455/jice.20150212103327. Epub 2015 Mar 3.
Since there is an increasing need for gastric ulcer therapies with optimum benefit-risk profile. This study was conducted to investigate gastro-protective effects of N-acetylcysteine (NAC) against ethanol-induced gastric ulcer models in mice.
A total of 41 mice were allocated into six groups consisted of 7 mice each. Groups 1 (normal control) and 2 (ulcer control) received distilled water at a dose of 10 ml/kg, groups 3, 4 and 5 were given NAC at doses 100, 300 and 500 mg/kg, respectively, and the 6(th) group received ranitidine (50 mg/kg). All drugs administered orally once daily for 7 days, on the 8(th) day absolute ethanol (7 ml/kg) was administrated orally to all mice to induce the acute ulcer except normal control group. Then 3 h after, all animals were sacrificed then consequently the stomachs were excised for examination.
NAC administration at the tested doses showed a dose-related potent gastro-protective effect with significant increase in curative ratio, PH of gastric juice and mucus content viscosity seen with the highest dose of NAC and it is comparable with that observed in ranitidine group.
The present findings demonstrate that, oral NAC shows significant gastro-protective effects comparable to ranitidine confirmed by anti-secretory, cytoprotective, histological and biochemical data, but the molecular mechanisms behind such protection are complex.
鉴于对具有最佳效益风险比的胃溃疡治疗方法的需求日益增加。本研究旨在探讨N-乙酰半胱氨酸（NAC）对乙醇诱导的小鼠胃溃疡模型的胃保护作用。
总共41只小鼠被分为六组，每组7只。第1组（正常对照组）和第2组（溃疡对照组）接受剂量为10 ml/kg的蒸馏水，第3、4和5组分别给予剂量为100、300和500 mg/kg的NAC，第6组接受雷尼替丁（50 mg/kg）。所有药物每日口服一次，持续7天，在第8天，除正常对照组外，所有小鼠口服绝对乙醇（7 ml/kg）以诱导急性溃疡。然后3小时后，处死所有动物，随后切除胃进行检查。
在所测试的剂量下给予NAC显示出与剂量相关的强大胃保护作用，治愈率、胃液pH值和黏液含量黏度显著增加，最高剂量的NAC效果最佳，且与雷尼替丁组相当。
目前的研究结果表明，口服NAC显示出与雷尼替丁相当的显著胃保护作用，抗分泌、细胞保护、组织学和生化数据均证实了这一点，但这种保护背后的分子机制很复杂。
