Department of Restorative Dentistry, Croydon University Hospital, 530 London Road, Croydon, Surrey CR7 7YE, UK.
Department of Physiology, Medical University of Bialystok, Mickiewicza 2c Str., 15-222 Bialystok, Poland.
Oxid Med Cell Longev. 2018 Jan 30;2018:6581970. doi: 10.1155/2018/6581970. eCollection 2018.
Oxidative stress plays a crucial role in the salivary gland dysfunction in insulin resistance (IR). It is not surprising that new substances are constantly being sought that will protect against the harmful effects of IR in the oral cavity environment. The purpose of this study was to evaluate the effect of N-acetylcysteine (NAC) on oxidative stress and secretory function of salivary glands in a rat model of insulin resistance. Rats were divided into 4 groups: C-normal diet, C + NAC-normal diet + NAC, HFD-high-fat diet, and HFD + NAC. We have demonstrated that NAC elevated enzymatic (superoxide dismutase, catalase, and peroxidase) and nonenzymatic antioxidants (reduced glutathione (GSH) and total antioxidant capacity (TAS)) in the parotid glands of HFD + NAC rats, while in the submandibular glands increased only GSH and TAS levels. NAC protects against oxidative damage only in the parotid glands and increased stimulated salivary secretion; however, it does not increase the protein secretion in the both salivary glands. Summarizing, NAC supplementation prevents the decrease of stimulated saliva secretion, seen in the HFD rats affected. NAC improves the antioxidative capacity of the both glands and protects against oxidative damage to the parotid glands of IR rats.
氧化应激在胰岛素抵抗（IR）中的唾液腺功能障碍中起着至关重要的作用。毫不奇怪，人们一直在不断寻找新的物质，以防止 IR 在口腔环境中产生有害影响。本研究旨在评估 N-乙酰半胱氨酸（NAC）对胰岛素抵抗大鼠模型唾液腺氧化应激和分泌功能的影响。大鼠分为 4 组：C-正常饮食、C+NAC-正常饮食+NAC、HFD-高脂肪饮食和 HFD+NAC。我们已经证明，NAC 可提高 HFD+NAC 大鼠腮腺中的酶（超氧化物歧化酶、过氧化氢酶和过氧化物酶）和非酶抗氧化剂（还原型谷胱甘肽 (GSH) 和总抗氧化能力 (TAS))，而在下颌下腺仅增加 GSH 和 TAS 水平。NAC 仅在腮腺中可防止氧化损伤，并增加刺激唾液分泌；然而，它不会增加两个唾液腺中的蛋白质分泌。综上所述，NAC 补充可防止 HFD 大鼠中观察到的刺激唾液分泌减少。NAC 可提高两个腺体的抗氧化能力，并防止 IR 大鼠的腮腺发生氧化损伤。
