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尼日利亚蜂胶乙醇提取物的保肝和保胰特性

Hepatoprotective and Pancreatoprotective Properties of the Ethanolic Extract of Nigerian Propolis.

作者信息

Babatunde Ibrahim Ridwan, Abdulbasit Amin, Oladayo Mustafa Ibrahim, Olasile Onanuga Ismail, Olamide Folarin Roehan, Gbolahan Balogun Wasiu

机构信息

Department of Anatomy, University of Ilorin, Ilorin, Nigeria.

Department of Physiology, University of Ilorin, Ilorin, Nigeria.

出版信息

J Intercult Ethnopharmacol. 2015 Apr-Jun;4(2):102-8. doi: 10.5455/jice.20150202023615. Epub 2015 Feb 16.

DOI:10.5455/jice.20150202023615
PMID:26401394
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4566782/
Abstract

OBJECTIVE

Increased oxidative stress is associated with the progression of diabetic mellitus. In the present study, we investigated the effects of the ethanolic extract of Nigerian propolis (N. propolis) on markers of oxidative stress, histology of the liver and pancreas and glycaemia in alloxan-induced diabetic rats.

MATERIALS AND METHODS

Alloxan-induced hyperglycemic Wistar rats were treated with either metformin (150 mg/kg/d) or N. propolis (200 mg/kg/d and 300 mg/kg/d) for 28 days. At the end of the treatment period, the rats were sacrificed; blood was collected for biochemical analysis while their pancreases and liver were excised and processed for histological studies.

RESULTS

Serum oxidative stress markers and blood glucose concentration were compared between the treated and control rats. In contrast to the non-treated diabetic rats, blood glucose concentration were not significantly different between treated rats and control (P < 0.05) at 28 days of treatment with N. propolis and metformin. Serum malondialdehyde levels was reduced while superoxide dismutase levels were elevated in the N. propolis group; these levels were converse in the diabetic group, these differences are statistically significant (P<0.05) when compared with the control. Histologically, there was improvement in the treated group compared to the untreated group.

CONCLUSION

These findings suggest that the N. propolis confers protection against hyperglycemia-induced oxidative stress in both liver and pancreas of adult Wistar rats.

摘要

目的

氧化应激增加与糖尿病的进展相关。在本研究中，我们调查了尼日利亚蜂胶（N.蜂胶）乙醇提取物对四氧嘧啶诱导的糖尿病大鼠氧化应激标志物、肝脏和胰腺组织学以及血糖的影响。

材料与方法

用二甲双胍（150毫克/千克/天）或N.蜂胶（200毫克/千克/天和300毫克/千克/天）对四氧嘧啶诱导的高血糖Wistar大鼠进行治疗，为期28天。在治疗期结束时，处死大鼠；采集血液进行生化分析，同时切除胰腺和肝脏并进行组织学研究。

结果

比较治疗组和对照组大鼠的血清氧化应激标志物和血糖浓度。与未治疗的糖尿病大鼠相比，在使用N.蜂胶和二甲双胍治疗28天时，治疗组大鼠与对照组之间的血糖浓度无显著差异（P<0.05）。N.蜂胶组血清丙二醛水平降低，而超氧化物歧化酶水平升高；糖尿病组则相反，与对照组相比，这些差异具有统计学意义（P<0.05）。组织学上，治疗组与未治疗组相比有改善。

结论

这些发现表明，N.蜂胶对成年Wistar大鼠肝脏和胰腺中高血糖诱导的氧化应激具有保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6f4/4566782/d09ff9aecae0/JIE-4-102-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6f4/4566782/d3dde302e741/JIE-4-102-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6f4/4566782/2cf0006d18e3/JIE-4-102-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6f4/4566782/7224672572ee/JIE-4-102-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6f4/4566782/1753a92e9b01/JIE-4-102-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6f4/4566782/04604d37a393/JIE-4-102-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6f4/4566782/d09ff9aecae0/JIE-4-102-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6f4/4566782/d3dde302e741/JIE-4-102-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6f4/4566782/2cf0006d18e3/JIE-4-102-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6f4/4566782/7224672572ee/JIE-4-102-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6f4/4566782/1753a92e9b01/JIE-4-102-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6f4/4566782/04604d37a393/JIE-4-102-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6f4/4566782/d09ff9aecae0/JIE-4-102-g008.jpg

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