蜂胶对健康志愿者空腹血糖、糖化血红蛋白及胰岛素抵抗的影响。
Effects of Bee Propolis on FBG, HbA1c, and Insulin Resistance in Healthy Volunteers.
作者信息
Alassaf Fawaz A, Jasim Mahmood H M, Alfahad Mohanad, Qazzaz Mohannad E, Abed Mohammed N, Thanoon Imad A-J
机构信息
Mosul University College of Pharmacy, Department of Pharmacology and Toxicology, Mosul, Iraq
Mosul University College of Pharmacy, Department of Pharmaceutical Chemistry, Mosul, Iraq
出版信息
Turk J Pharm Sci. 2021 Sep 1;18(4):405-409. doi: 10.4274/tjps.galenos.2020.50024.
Abstract
OBJECTIVES
Bee propolis is a natural substance that is used in traditional medicine due to its versatile pharmacological actions. This study evaluates whether short term use of bee propolis supplementation could have an impact on glycemic control in healthy individuals.
MATERIALS AND METHODS
A single daily dose of 1000 mg of bee propolis was administered orally to a total of 34 healthy individuals for 60 days. Body weight, body mass index (BMI), fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), and insulin resistance were measured in all participants before and after the use of bee propolis.
RESULTS
The results of this study showed that bee propolis was associated with a significant increase in body weight and BMI of healthy volunteers. Bee propolis supplementation decreased FBG and HbA1c, but did not affect insulin resistance.
CONCLUSION
Based on these results, bee propolis supplementation has a potential effect on glycemic control in healthy individuals and this should be considered when using this supplement in medical conditions.
摘要
目的
蜂胶是一种天然物质，因其多样的药理作用而被用于传统医学。本研究评估短期补充蜂胶是否会对健康个体的血糖控制产生影响。
材料与方法
共34名健康个体口服每日单剂量1000毫克蜂胶，持续60天。在所有参与者使用蜂胶前后测量体重、体重指数（BMI）、空腹血糖（FBG）、糖化血红蛋白（HbA1c）和胰岛素抵抗。
结果
本研究结果表明，蜂胶与健康志愿者的体重和BMI显著增加有关。补充蜂胶可降低FBG和HbA1c，但不影响胰岛素抵抗。
结论
基于这些结果，补充蜂胶对健康个体的血糖控制有潜在作用，在医疗状况下使用这种补充剂时应予以考虑。
相似文献
1
Effects of Bee Propolis on FBG, HbA1c, and Insulin Resistance in Healthy Volunteers.蜂胶对健康志愿者空腹血糖、糖化血红蛋白及胰岛素抵抗的影响。
Turk J Pharm Sci. 2021 Sep 1;18(4):405-409. doi: 10.4274/tjps.galenos.2020.50024.
2
Effects of bee propolis supplementation on glycemic control, lipid profile and insulin resistance indices in patients with type 2 diabetes: a randomized, double-blind clinical trial.补充蜂胶对2型糖尿病患者血糖控制、血脂水平及胰岛素抵抗指标的影响：一项随机双盲临床试验
J Integr Med. 2017 Mar;15(2):124-134. doi: 10.1016/S2095-4964(17)60315-7.
3
Propolis modulates the gut microbiota and improves the intestinal mucosal barrier function in diabetic rats.蜂胶调节糖尿病大鼠的肠道微生物群，并改善肠道黏膜屏障功能。
Biomed Pharmacother. 2019 Oct;118:109393. doi: 10.1016/j.biopha.2019.109393. Epub 2019 Sep 2.
4
Effect of antioxidant-rich propolis and bee pollen extracts against D-glucose induced type 2 diabetes in rats.富含抗氧化剂的蜂胶和蜂花粉提取物对D-葡萄糖诱导的大鼠2型糖尿病的影响。
Food Res Int. 2020 Dec;138(Pt B):109802. doi: 10.1016/j.foodres.2020.109802. Epub 2020 Oct 15.
5
Growth performance, carcass quality, biochemical and haematological traits and immune response of growing rabbits as affected by different growth promoters.生长性能、胴体质量、生化和血液学特性以及生长兔的免疫反应受不同生长促进剂的影响。
J Anim Physiol Anim Nutr (Berl). 2014 Feb;98(1):128-39. doi: 10.1111/jpn.12056. Epub 2013 Feb 18.
6
Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen.蜂疗用于治疗与年龄相关的骨骼肌功能障碍（肌肉减少症）：关于蜂王浆、蜂胶和蜂花粉作用的综述
Foods. 2020 Sep 25;9(10):1362. doi: 10.3390/foods9101362.
7
Glycemic control and anti-osteopathic effect of propolis in diabetic rats.蜂胶对糖尿病大鼠血糖控制和抗骨质疏松作用。
Diabetes Metab Syndr Obes. 2011;4:377-84. doi: 10.2147/DMSO.S24159. Epub 2011 Nov 22.
8
Improvement of insulin resistance, blood pressure and interstitial pH in early developmental stage of insulin resistance in OLETF rats by intake of propolis extracts.蜂胶提取物可改善 OLETF 大鼠胰岛素抵抗早期发展阶段的胰岛素抵抗、血压和间质 pH 值。
Biochem Biophys Res Commun. 2013 Mar 22;432(4):650-3. doi: 10.1016/j.bbrc.2013.02.029. Epub 2013 Feb 14.
9
Water-soluble propolis and bee pollen of spp. from South Sulawesi Indonesia induce apoptosis in the human breast cancer MCF-7 cell line.来自印度尼西亚南苏拉威西的水溶性蜂胶和 spp. 的蜂花粉可诱导人乳腺癌MCF-7细胞系凋亡。
Oncol Lett. 2020 Nov;20(5):274. doi: 10.3892/ol.2020.12137. Epub 2020 Sep 21.
10
[Acupuncture Treatment Reduces Body Weight Possibly by Down-regulating Insulin and Leptin Resistance, and Up-regulating Soluble Leptin Receptor Level in Prediabetic Patients].[针刺治疗可能通过下调胰岛素和瘦素抵抗以及上调糖尿病前期患者可溶性瘦素受体水平来减轻体重]
Zhen Ci Yan Jiu. 2018 Aug 25;43(8):506-11. doi: 10.13702/j.1000-0607.180184.
引用本文的文献
1
Incretin-Based Therapies: A Promising Approach for Modulating Oxidative Stress and Insulin Resistance in Sarcopenia.基于肠促胰岛素的疗法：调节肌肉减少症中氧化应激和胰岛素抵抗的一种有前景的方法。
J Bone Metab. 2024 Nov;31(4):251-263. doi: 10.11005/jbm.24.739. Epub 2024 Nov 4.
2
Antidiabetic Agents and Bone Quality: A Focus on Glycation End Products and Incretin Pathway Modulations.抗糖尿病药物与骨质量：聚焦糖基化终产物和肠促胰岛素途径调节
J Bone Metab. 2024 Aug;31(3):169-181. doi: 10.11005/jbm.2024.31.3.169. Epub 2024 Aug 31.
3
Effects of Propolis Consumption on Liver Enzymes and Obesity Indices in Adults: A Systematic Review and Dose-Response Meta-Analysis.蜂胶消费对成年人肝脏酶和肥胖指数的影响：系统评价与剂量反应荟萃分析
Curr Dev Nutr. 2024 Aug 13;8(9):104438. doi: 10.1016/j.cdnut.2024.104438. eCollection 2024 Sep.
4
Exploring the Interplay between Vitamin D, Insulin Resistance, Obesity and Skeletal Health.探索维生素D、胰岛素抵抗、肥胖与骨骼健康之间的相互作用。
J Bone Metab. 2024 May;31(2):75-89. doi: 10.11005/jbm.2024.31.2.75. Epub 2024 May 31.
5
Propolis and its constituents against cardiovascular risk factors including obesity, hypertension, atherosclerosis, diabetes, and dyslipidemia: A comprehensive review.蜂胶及其成分对抗包括肥胖、高血压、动脉粥样硬化、糖尿病和血脂异常在内的心血管危险因素：一项综述。
Iran J Basic Med Sci. 2023;26(8):853-871. doi: 10.22038/IJBMS.2023.67793.14835.
6
Effect of propolis on mood, quality of life, and metabolic profiles in subjects with metabolic syndrome: a randomized clinical trial.蜂胶对代谢综合征患者情绪、生活质量和代谢特征的影响：一项随机临床试验。
Sci Rep. 2023 Mar 17;13(1):4452. doi: 10.1038/s41598-023-31254-y.
本文引用的文献
1
The Effect of Iranian Propolis on Glucose Metabolism, Lipid Profile, Insulin Resistance, Renal Function and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Clinical Trial.伊朗蜂胶对 2 型糖尿病患者糖代谢、血脂谱、胰岛素抵抗、肾功能和炎症生物标志物的影响：一项随机双盲临床试验。
Sci Rep. 2019 May 13;9(1):7289. doi: 10.1038/s41598-019-43838-8.
2
Hypoglycaemic and Antioxidant Effects of Propolis of Chihuahua in a Model of Experimental Diabetes.奇瓦瓦蜂胶在实验性糖尿病模型中的降血糖和抗氧化作用
Evid Based Complement Alternat Med. 2018 Mar 11;2018:4360356. doi: 10.1155/2018/4360356. eCollection 2018.
3
Brazilian Green Propolis Promotes Weight Loss and Reduces Fat Accumulation in C57BL/6 Mice Fed A High-Fat Diet.巴西绿蜂胶可促进高脂饮食喂养的C57BL/6小鼠体重减轻并减少脂肪堆积。
Biol Pharm Bull. 2017;40(4):391-395. doi: 10.1248/bpb.b16-00577.
4
Effects of green tea supplementation on inflammation markers, antioxidant status and blood pressure in NaCl-induced hypertensive rat model.绿茶补充剂对氯化钠诱导的高血压大鼠模型中炎症标志物、抗氧化状态和血压的影响。
Food Nutr Res. 2017 Mar 3;61(1):1295525. doi: 10.1080/16546628.2017.1295525. eCollection 2017.
5
Effects of bee propolis supplementation on glycemic control, lipid profile and insulin resistance indices in patients with type 2 diabetes: a randomized, double-blind clinical trial.补充蜂胶对2型糖尿病患者血糖控制、血脂水平及胰岛素抵抗指标的影响：一项随机双盲临床试验
J Integr Med. 2017 Mar;15(2):124-134. doi: 10.1016/S2095-4964(17)60315-7.
6
Nigerian propolis improves blood glucose, glycated hemoglobin A1c, very low-density lipoprotein, and high-density lipoprotein levels in rat models of diabetes.尼日利亚蜂胶可改善糖尿病大鼠模型的血糖、糖化血红蛋白A1c、极低密度脂蛋白和高密度脂蛋白水平。
J Intercult Ethnopharmacol. 2016 May 4;5(3):233-8. doi: 10.5455/jice.20160502065029. eCollection 2016 Jun-Aug.
7
Effects of ethanol extract of propolis on histopathological changes and anti-oxidant defense of kidney in a rat model for type 1 diabetes mellitus.蜂胶乙醇提取物对1型糖尿病大鼠模型肾脏组织病理学变化及抗氧化防御的影响
J Diabetes Investig. 2016 Jul;7(4):506-13. doi: 10.1111/jdi.12459. Epub 2016 May 28.
8
Antioxidant activities and molecular mechanisms of the ethanol extracts of Baccharis propolis and Eucalyptus propolis in RAW64.7 cells.巴西蜂胶和桉属蜂胶乙醇提取物在RAW64.7细胞中的抗氧化活性及分子机制
Pharm Biol. 2016 Oct;54(10):2220-35. doi: 10.3109/13880209.2016.1151444. Epub 2016 Apr 6.
9
myo-Inositol Oxygenase Overexpression Accentuates Generation of Reactive Oxygen Species and Exacerbates Cellular Injury following High Glucose Ambience: A NEW MECHANISM RELEVANT TO THE PATHOGENESIS OF DIABETIC NEPHROPATHY.肌醇加氧酶过表达加剧高糖环境下活性氧的生成并加重细胞损伤：一种与糖尿病肾病发病机制相关的新机制
J Biol Chem. 2016 Mar 11;291(11):5688-5707. doi: 10.1074/jbc.M115.669952. Epub 2016 Jan 20.
10
Antiproliferative and proapoptotic activity of Turkish propolis on human lung cancer cell line.土耳其蜂胶对人肺癌细胞系的抗增殖和促凋亡活性。
Nutr Cancer. 2016;68(1):165-72. doi: 10.1080/01635581.2016.1115096. Epub 2015 Dec 23.
Zotero 插件