Yin Rui-Hua, Tan Lan, Liu Yong, Wang Wen-Ying, Wang Hui-Fu, Jiang Teng, Radua Joaquim, Zhang Yu, Gao Junling, Canu Elisa, Migliaccio Raffaella, Filippi Massimo, Gorno-Tempini Maria Luisa, Yu Jin-Tai
Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China.
College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China.
J Alzheimers Dis. 2015;47(2):495-507. doi: 10.3233/JAD-150139.
An increasing number of MRI investigations suggest that patients with Alzheimer's disease (AD) show not only gray matter decreases but also white matter (WM) abnormalities, including WM volume (WMV) deficits and integrity disruption of WM pathways. In this study, we applied multimodal voxel-wise meta-analytical methods to study WMV and fractional anisotropy in AD. Fourteen studies including 723 participants (340 with AD and 383 controls) were involved. The meta-analysis was performed using effect size signed differential mapping. Significant WMV reductions were observed in bilateral inferior temporal gyrus, splenium of corpus callosum, right parahippocampal gyrus, and hippocampus. Decreased fractional anisotropy was identified mainly in left posterior limb of internal capsule, left anterior corona radiata, left thalamus, and left caudate nucleus. Significant decreases of both WMV and fractional anisotropy were found in left caudate nucleus, left superior corona radiata, and right inferior temporal gyrus. Most findings showed to be highly replicable in the jackknife sensitivity analyses. In conclusion, AD patients show widespread WM abnormalities mainly in bilateral structures related to advanced mental and nervous activities.
越来越多的磁共振成像（MRI）研究表明，阿尔茨海默病（AD）患者不仅存在灰质减少，还存在白质（WM）异常，包括白质体积（WMV） deficits和白质通路完整性破坏。在本研究中，我们应用多模态体素级荟萃分析方法研究AD患者的WMV和分数各向异性。纳入了14项研究，共723名参与者（340例AD患者和383例对照）。使用效应量符号差异映射进行荟萃分析。在双侧颞下回、胼胝体压部、右侧海马旁回和海马中观察到显著的WMV减少。分数各向异性降低主要见于左侧内囊后肢、左侧放射冠前部、左侧丘脑和左侧尾状核。在左侧尾状核、左侧放射冠上部和右侧颞下回中发现WMV和分数各向异性均显著降低。大多数研究结果在留一法敏感性分析中显示出高度可重复性。总之，AD患者存在广泛的WM异常，主要集中在与高级精神和神经活动相关的双侧结构中。
