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家庭中儿童中毒的预防:系统评价概述及原始研究的系统评价

Prevention of childhood poisoning in the home: overview of systematic reviews and a systematic review of primary studies.

作者信息

Wynn Persephone M, Zou Kun, Young Ben, Majsak-Newman Gosia, Hawkins Adrian, Kay Bryony, Mhizha-Murira Jacqueline, Kendrick Denise

机构信息

a Division of Primary Care , University of Nottingham , Nottingham , UK.

b NHS Clinical Research and Trials Unit, Norwich Medical School , University of East Anglia , Norwich , UK.

出版信息

Int J Inj Contr Saf Promot. 2016;23(1):3-28. doi: 10.1080/17457300.2015.1032978. Epub 2015 Sep 24.

Abstract

Unintentional poisoning is a significant child public health problem. This systematic overview of reviews, supplemented with a systematic review of recently published primary studies synthesizes evidence on non-legislative interventions to reduce childhood poisonings in the home with particular reference to interventions that could be implemented by Children's Centres in England or community health or social care services in other high income countries. Thirteen systematic reviews, two meta-analyses and 47 primary studies were identified. The interventions most commonly comprised education, provision of cupboard/drawer locks, and poison control centre (PCC) number stickers. Meta-analyses and primary studies provided evidence that interventions improved poison prevention practices. Twenty eight per cent of studies reporting safe medicine storage (OR from meta-analysis 1.57, 95% CI 1.22-2.02), 23% reporting safe storage of other products (OR from meta-analysis 1.63, 95% CI 1.22-2.17) and 46% reporting availability of PCC numbers (OR from meta-analysis 3.67, 95% CI 1.84-7.33) demonstrated significant effects favouring the intervention group. There was a lack of evidence that interventions reduced poisoning rates. Parents should be provided with poison prevention education, cupboard/drawer locks and emergency contact numbers to use in the event of a poisoning. Further research is required to determine whether improving poison prevention practices reduces poisoning rates.

摘要

意外中毒是一个严重的儿童公共卫生问题。本综述的系统概述,辅以对近期发表的原始研究的系统评价,综合了关于减少家庭中儿童中毒的非立法干预措施的证据,特别提及了英格兰儿童中心或其他高收入国家的社区卫生或社会护理服务可以实施的干预措施。共识别出13项系统评价、2项荟萃分析和47项原始研究。最常见的干预措施包括教育、提供橱柜/抽屉锁以及中毒控制中心(PCC)号码贴纸。荟萃分析和原始研究提供的证据表明,这些干预措施改善了中毒预防措施。报告安全储存药品的研究中有28%(荟萃分析的OR为1.57,95%CI为1.22 - 2.02),报告其他产品安全储存的研究中有23%(荟萃分析的OR为1.63,95%CI为1.22 - 2.17),报告有PCC号码的研究中有46%(荟萃分析的OR为3.67,95%CI为1.84 - 7.33)显示干预组有显著效果。缺乏证据表明干预措施能降低中毒率。应向家长提供中毒预防教育、橱柜/抽屉锁以及中毒时使用的紧急联系电话。需要进一步研究以确定改善中毒预防措施是否能降低中毒率。

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