具有核靶向的尺寸可变化的纳米载体，可有效克服癌症治疗中的多药耐药性。
Size Changeable Nanocarriers with Nuclear Targeting for Effectively Overcoming Multidrug Resistance in Cancer Therapy.
机构信息
Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, P.R. China.
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, P.R. China.
出版信息
Adv Mater. 2015 Nov 4;27(41):6450-6. doi: 10.1002/adma.201502865. Epub 2015 Sep 24.
A size changeable polymer micelle system with a dual shell, which increases in size under acidic pH conditions and is altered to smaller micelles, triggered by intracellular glutathione (GSH), is successfully developed. It is capable of direct delivering anticancer drugs to the nucleus of multidrug resistance (MDR) tumor cells for highly effective combating of drug resistant breast cancer.
一种具有双壳的可尺寸变化的聚合物胶束系统，在酸性 pH 条件下会增加尺寸，并在细胞内谷胱甘肽 (GSH) 的触发下转变为更小的胶束，成功开发。它能够将抗癌药物直接递送至多药耐药 (MDR) 肿瘤细胞的核内，从而高效对抗耐药性乳腺癌。
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