• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

具有核靶向的尺寸可变化的纳米载体，可有效克服癌症治疗中的多药耐药性。

Size Changeable Nanocarriers with Nuclear Targeting for Effectively Overcoming Multidrug Resistance in Cancer Therapy.

机构信息

Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, P.R. China.

School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, P.R. China.

出版信息

Adv Mater. 2015 Nov 4;27(41):6450-6. doi: 10.1002/adma.201502865. Epub 2015 Sep 24.

DOI:10.1002/adma.201502865
PMID:26401989
Abstract

A size changeable polymer micelle system with a dual shell, which increases in size under acidic pH conditions and is altered to smaller micelles, triggered by intracellular glutathione (GSH), is successfully developed. It is capable of direct delivering anticancer drugs to the nucleus of multidrug resistance (MDR) tumor cells for highly effective combating of drug resistant breast cancer.

摘要

一种具有双壳的可尺寸变化的聚合物胶束系统，在酸性 pH 条件下会增加尺寸，并在细胞内谷胱甘肽 (GSH) 的触发下转变为更小的胶束，成功开发。它能够将抗癌药物直接递送至多药耐药 (MDR) 肿瘤细胞的核内，从而高效对抗耐药性乳腺癌。

相似文献

1
Size Changeable Nanocarriers with Nuclear Targeting for Effectively Overcoming Multidrug Resistance in Cancer Therapy.具有核靶向的尺寸可变化的纳米载体，可有效克服癌症治疗中的多药耐药性。
Adv Mater. 2015 Nov 4;27(41):6450-6. doi: 10.1002/adma.201502865. Epub 2015 Sep 24.
2
Micelles of d-α-Tocopheryl Polyethylene Glycol 2000 Succinate (TPGS 2K) for Doxorubicin Delivery with Reversal of Multidrug Resistance.用于阿霉素递送及逆转多药耐药性的琥珀酸聚乙二醇2000 d-α-生育酚（TPGS 2K）胶束
ACS Appl Mater Interfaces. 2015 Aug 19;7(32):18064-75. doi: 10.1021/acsami.5b04995. Epub 2015 Aug 5.
3
Synthesis of Size-Tunable Hollow Polypyrrole Nanostructures and Their Assembly into Folate-Targeting and pH-Responsive Anticancer Drug-Delivery Agents.尺寸可调的空心聚吡咯纳米结构的合成及其组装成叶酸靶向和pH响应型抗癌药物递送剂
Chemistry. 2017 Dec 6;23(68):17279-17289. doi: 10.1002/chem.201702945. Epub 2017 Nov 14.
4
Targeted doxorubicin nanotherapy strongly suppressing growth of multidrug resistant tumor in mice.靶向阿霉素纳米治疗强烈抑制小鼠多药耐药肿瘤的生长。
Int J Pharm. 2015 Nov 10;495(1):329-335. doi: 10.1016/j.ijpharm.2015.08.083. Epub 2015 Sep 14.
5
Aminoglucose-functionalized, redox-responsive polymer nanomicelles for overcoming chemoresistance in lung cancer cells.氨基葡萄糖功能化、氧化还原响应聚合物纳米胶束克服肺癌细胞的化疗耐药性。
J Nanobiotechnology. 2017 Nov 28;15(1):87. doi: 10.1186/s12951-017-0316-z.
6
Investigation on vitamin e succinate based intelligent hyaluronic acid micelles for overcoming drug resistance and enhancing anticancer efficacy.基于琥珀酸维生素 E 的智能透明质酸胶束克服耐药性和增强抗癌疗效的研究。
Eur J Pharm Sci. 2019 Dec 1;140:105071. doi: 10.1016/j.ejps.2019.105071. Epub 2019 Sep 13.
7
Tumor-targeting, pH-responsive, and stable unimolecular micelles as drug nanocarriers for targeted cancer therapy.用于靶向癌症治疗的肿瘤靶向、pH响应且稳定的单分子胶束作为药物纳米载体。
Bioconjug Chem. 2010 Mar 17;21(3):496-504. doi: 10.1021/bc900422j. Epub 2010 Feb 17.
8
Comparison of hyaluronic acid-based micelles and polyethylene glycol-based micelles on reversal of multidrug resistance and enhanced anticancer efficacy in vitro and in vivo.比较基于透明质酸的胶束和基于聚乙二醇的胶束对逆转多药耐药性和增强体内外抗肿瘤疗效的作用。
Drug Deliv. 2018 Nov;25(1):330-340. doi: 10.1080/10717544.2018.1428385.
9
A glutathione-responsive sulfur dioxide polymer prodrug as a nanocarrier for combating drug-resistance in cancer chemotherapy.一种响应谷胱甘肽的二氧化硫聚合物前药作为纳米载体用于克服癌症化疗中的耐药性。
Biomaterials. 2018 Sep;178:706-719. doi: 10.1016/j.biomaterials.2018.02.011. Epub 2018 Feb 3.
10
Tumor-targeted micelle-forming block copolymers for overcoming of multidrug resistance.用于克服多药耐药性的肿瘤靶向胶束形成嵌段共聚物。
J Control Release. 2017 Jan 10;245:41-51. doi: 10.1016/j.jconrel.2016.11.020. Epub 2016 Nov 18.

引用本文的文献

1
Tumor Microenvironment Responsive TPZ-Loaded Core-Shell Polymeric Nanoparticles for Selective Cancer Bioreductive Therapy.用于选择性癌症生物还原治疗的肿瘤微环境响应性载有替拉扎明的核壳聚合物纳米颗粒
Adv Pharm Bull. 2025 Jun 16;15(2):390-405. doi: 10.34172/apb.025.43945. eCollection 2025 Jul.
2
Nanomedicine in Cancer Therapeutics: Current Perspectives from Bench to Bedside.癌症治疗中的纳米医学：从实验室到临床的当前视角
Mol Cancer. 2025 Jun 9;24(1):169. doi: 10.1186/s12943-025-02368-w.
3
Size-transformable nanotherapeutics for cancer therapy.
用于癌症治疗的尺寸可变换纳米治疗剂。
Acta Pharm Sin B. 2025 Feb;15(2):834-851. doi: 10.1016/j.apsb.2024.11.012. Epub 2024 Nov 25.
4
Dimeric Drug Polymeric Micelles with Acid-Active Tumor Targeting and FRET-indicated Drug Release.具有酸活性肿瘤靶向和FRET指示药物释放的二聚体药物聚合物胶束
ArXiv. 2024 Jul 30:arXiv:2407.20538v1.
5
Advances in 2,3-Dimethylmaleic Anhydride (DMMA)-Modified Nanocarriers in Drug Delivery Systems.2,3-二甲基马来酸酐（DMMA）修饰的纳米载体在药物递送系统中的研究进展
Pharmaceutics. 2024 Jun 14;16(6):809. doi: 10.3390/pharmaceutics16060809.
6
Development of an aptamer capable of multidrug resistance reversal for tumor combination chemotherapy.开发一种适体，用于逆转肿瘤联合化疗的多药耐药性。
Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2321116121. doi: 10.1073/pnas.2321116121. Epub 2024 Apr 1.
7
pH/redox responsive size-switchable intelligent nanovehicle for tumor microenvironment targeted DOX release.用于肿瘤微环境靶向 DOX 释放的 pH/氧化还原响应型尺寸可切换智能纳米载体。
Sci Rep. 2023 Dec 18;13(1):22475. doi: 10.1038/s41598-023-49446-x.
8
Nanodelivery systems: An efficient and target-specific approach for drug-resistant cancers.纳米递送系统：一种针对耐药性癌症的高效且靶向性方法。
Cancer Med. 2023 Sep;12(18):18797-18825. doi: 10.1002/cam4.6502. Epub 2023 Sep 5.
9
Nanomedicine in cancer therapy.癌症治疗中的纳米医学。
Signal Transduct Target Ther. 2023 Aug 7;8(1):293. doi: 10.1038/s41392-023-01536-y.
10
Multifunctional nanostructures: Intelligent design to overcome biological barriers.多功能纳米结构：克服生物屏障的智能设计
Mater Today Bio. 2023 May 18;20:100672. doi: 10.1016/j.mtbio.2023.100672. eCollection 2023 Jun.