Kalinová Zuzana, Halánová Monika, Čisláková Lýdia, Juriš Peter
Faculty of Medicine, Department of Epidemiology, P. J. Šafárik University, Košice, Slovak Republic.
Ann Agric Environ Med. 2015;22(3):409-11. doi: 10.5604/12321966.1167702.
Human granulocytic anaplasmosis (HGA) is an emerging tick-borne infectious disease caused by Anaplasma phagocytophilum. In Europe, the first serological evidence of HGA was described in 1995 in Switzerland, and the first clinical case was confirmed in 1997 in Slovenia. Since then, many European countries, including Slovakia, have reported the occurrence of HGA. The aim of this study was to examine the occurrence of IgG antibodies against A. phagocytophilum in blood sera of humans with suspected tick-borne encephalitis.
181 people were examined for the presence of anti-A. phagocytophilum IgG antibodies; 113 were patients with suspected TBE (65 males, 48 females), and 68 from the control group (18 males, 50 females). Respondents were aged 2-80 years (mean age: 31.39; STD: 17.1). Anti-A. phagocytophilum IgG antibodies were detected by the IFA IgG test. Relative risk (RR) and their 95% confidence intervals (95% CI) were estimated for the occurrence of IgG A. phagocytophilum antibodies.
Of the total number of 181 people examined, 32 (17.7%) showed positive for IgG antibodies against A. phagocytophilum, 22 of whom were patients with suspected TBE (19.5%) and 10 people from control group (14.7%). The RR of occurrence of IgG A. phagocytophilum was 1.3-times higher in the patients with suspected TBE than in the control group.
None of the examined patients with suspected TBE had the disease confirmed. Hoever, as shown by the results, the relative risk of occurrence of anaplasmosis is higher in people examined for some another vector-borne disease (in this case TBE). Therefore, the performance of screening examinations in patients suspected of having any tick-borne disease is very important.
人粒细胞无形体病（HGA）是一种由嗜吞噬细胞无形体引起的新发蜱传感染性疾病。在欧洲，1995年在瑞士首次描述了HGA的血清学证据，1997年在斯洛文尼亚确诊了首例临床病例。从那时起，包括斯洛伐克在内的许多欧洲国家都报告了HGA的发生情况。本研究的目的是检测疑似蜱传脑炎患者血清中抗嗜吞噬细胞无形体IgG抗体的出现情况。
对181人进行了抗嗜吞噬细胞无形体IgG抗体检测；其中113例为疑似蜱传脑炎患者（男性65例，女性48例），68例来自对照组（男性18例，女性50例）。受访者年龄在2至80岁之间（平均年龄：31.39岁；标准差：17.1岁）。通过间接荧光抗体IgG试验检测抗嗜吞噬细胞无形体IgG抗体。估计了嗜吞噬细胞无形体IgG抗体出现的相对风险（RR）及其95%置信区间（95%CI）。
在总共181名受检者中，32人（17.7%）抗嗜吞噬细胞无形体IgG抗体呈阳性，其中22例为疑似蜱传脑炎患者（19.5%），10例来自对照组（14.7%）。疑似蜱传脑炎患者中嗜吞噬细胞无形体IgG出现的RR比对照组高1.3倍。
所有受检的疑似蜱传脑炎患者均未确诊该病。然而，结果显示，在接受其他媒介传播疾病（本例为蜱传脑炎）检查的人群中，无形体病发生的相对风险更高。因此，对疑似患有任何蜱传疾病的患者进行筛查检查非常重要。
