Department of Microbiology, General Hospital of Førde , Førde , Norway.
Infect Dis (Lond). 2015 Jan;47(1):52-6. doi: 10.3109/00365548.2014.959044. Epub 2014 Oct 24.
The aim of this study was to assess the seroprevalence of antibodies to tick-borne encephalitis virus (TBEV) and Anaplasma phagocytophilum in a healthy adult population from Sogn and Fjordane county in western Norway. Sera from 1, 213 blood donors were analysed for IgG-antibodies to TBEV, and a random subgroup of 301 donors for IgG to A. phagocytophilum. In the TBEV ELISA, five (0.4%) sera were positive. These were all interpreted as "false" positives, as four had received vaccines against flaviviruses, and the remaining was negative for neutralizing antibodies to TBEV. Antibodies to A. phagocytophilum were detected by indirect immunofluorescence in 49 (16.2%) subjects (titer range 80-1280). The results indicate that TBE currently is not endemic in this part of western Norway. However, there is serological evidence of the existence of human granulocytic anaplasmosis in the population.
本研究旨在评估来自挪威西部松恩-菲尤拉讷郡的健康成年人群中，感染蜱传脑炎病毒（TBEV）和嗜吞噬细胞无形体的血清抗体阳性率。对 1213 名献血者的血清进行 TBEV IgG 抗体分析，对 301 名献血者的随机亚组进行 IgG 嗜吞噬细胞无形体抗体分析。在 TBEV ELISA 中，有 5 份（0.4%）血清呈阳性。这些均被解释为“假阳性”，因为其中 4 份曾接种过黄病毒疫苗，而其余的 TBEV 中和抗体呈阴性。间接免疫荧光法检测到 49 份（16.2%）样本存在嗜吞噬细胞无形体抗体（滴度范围 80-1280）。结果表明，TBE 目前在挪威西部的这一地区并非地方性疾病。然而，人群中存在人类粒细胞无形体病的血清学证据。
