State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun, Jilin 130022, P. R. China.
Chemistry and Life Science School, Advanced Institute of Materials Science, Changchun University of Technology , 2055 Yanan Street, Changchun, Jilin 130012, P. R. China.
ACS Appl Mater Interfaces. 2015 Oct 14;7(40):22181-7. doi: 10.1021/acsami.5b04315. Epub 2015 Sep 30.
A straightforward nanoprecipitating method was developed to prepare water dispersible curcumin (CCM)-loaded nanoscale zeolitic imidazolate framework-8 (CCM@NZIF-8) nanoparticles (NPs). The as-synthesized CCM@NZIF-8 NPs possess high drug encapsulation efficiency (88.2%), good chemical stability and fast drug release in tumor acidic microenvironments. Confocal laser scanning microscopy and cytotoxicity experiments reveal that NZIF-8 based nanocarriers promote the cellular uptake of CCM and result in higher cytotoxicity of CCM@NZIF-8 than that of free CCM toward HeLa cells. The in vivo anticancer experiments indicate that CCM@NZIF-8 NPs exhibit much higher antitumor efficacy than free CCM. This work highlights the potential of using nanoscale metal organic framworks (NMOFs) as a simple and stable platform for developing a highly efficient drug delivery system in cancer treatment.
一种简单的纳米沉淀法被开发用来制备水可分散的姜黄素（CCM）负载的纳米沸石咪唑酯骨架-8（CCM@NZIF-8）纳米颗粒（NPs）。所合成的 CCM@NZIF-8 NPs 具有高药物包封效率（88.2%）、良好的化学稳定性和在肿瘤酸性微环境中的快速药物释放。共聚焦激光扫描显微镜和细胞毒性实验表明，基于 NZIF-8 的纳米载体促进了 CCM 的细胞摄取，使 CCM@NZIF-8 对 HeLa 细胞的细胞毒性高于游离 CCM。体内抗癌实验表明，CCM@NZIF-8 NPs 比游离 CCM 具有更高的抗肿瘤疗效。这项工作突出了使用纳米尺度金属有机骨架（NMOFs）作为开发高效药物输送系统治疗癌症的简单而稳定平台的潜力。
