Rahman Mahbubur, Kabir Mohashin, Islam Tarikul, Wang Yafei, Meng Qi, Liu Hailei, Chen Shaojuan, Wu Shaohua
State Key Laboratory of Bio-Fibers and Eco-Textiles, College of Textiles and Clothing, Qingdao University, Qingdao 266071, China.
Department of Textile Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail 1902, Bangladesh.
ACS Omega. 2025 Jan 14;10(3):3067-3079. doi: 10.1021/acsomega.4c09945. eCollection 2025 Jan 28.
Curcumin (cur) possesses excellent therapeutic properties, including anti-inflammatory, antioxidant, and healing-promoting effects. However, its biomedical application is impeded by its rapid degradation, limited bioavailability, and poor aqueous solubility. Zeolitic imidazole framework (ZIF-8), with a high surface area and tunable pore size, is designed and used as a cur delivery carrier to overcome these limitations. The synthesis of cur-loaded ZIF-8 involves a solvothermal method, followed by encapsulation of cur within the porous structure of ZIF-8. The amount of cur was varied to synthesize a series of panel cur-loaded ZIF-8. 0.5 mg/mL cur@ZIF-8 that showed higher drug loading efficiency (85.91 ± 1.26%) and drug loading capability (12.93 ± 0.19%) without changes in shape, size, crystallinity, chemical composition, and thermal stability of original ZIF-8. 0.5 mg/mL cur@ZIF-8 exhibited excellent surface area (1591.02 m/g) and micropore volume (0.54 cm/g). Cur@ZIF-8 demonstrated superior thermal stability and outstanding antibacterial properties, achieving 99% efficiency compared with free cur. It exhibited less cytotoxicity against human fibroblast cells and better antioxidant properties than ZIF-8. Furthermore, the drug release rate of cur@ZIF-8 is higher under acidic conditions, which promotes wound healing due to the acidic microenvironment of the skin. The biocompatibility and stability of cur@ZIF-8 nanoparticles highlight their potential as promising candidates for diverse biomedical applications.
姜黄素（Cur）具有出色的治疗特性，包括抗炎、抗氧化和促进愈合的作用。然而，其快速降解、有限的生物利用度和较差的水溶性阻碍了其生物医学应用。具有高表面积和可调孔径的沸石咪唑框架（ZIF-8）被设计并用作姜黄素递送载体以克服这些限制。负载姜黄素的ZIF-8的合成涉及溶剂热法，随后将姜黄素封装在ZIF-8的多孔结构中。改变姜黄素的量以合成一系列负载姜黄素的ZIF-8。0.5mg/mL的姜黄素@ZIF-8显示出更高的载药效率（85.91±1.26%）和载药能力（12.93±0.19%），同时原始ZIF-8的形状、尺寸、结晶度、化学成分和热稳定性没有变化。0.5mg/mL的姜黄素@ZIF-8表现出出色的表面积（1591.02m/g）和微孔体积（0.54cm/g）。姜黄素@ZIF-8表现出优异的热稳定性和出色的抗菌性能，与游离姜黄素相比效率达到99%。与ZIF-8相比，它对人成纤维细胞的细胞毒性更小，抗氧化性能更好。此外，姜黄素@ZIF-8在酸性条件下的药物释放速率更高，由于皮肤的酸性微环境，这促进了伤口愈合。姜黄素@ZIF-8纳米颗粒的生物相容性和稳定性突出了它们作为多种生物医学应用有前景候选物的潜力。
