Yin Hang, Sun Yuqiang, Wang Xiaofeng, Park Jeiyoun, Zhang Yuanyang, Li Molin, Yin Jian, Liu Qiang, Wei Minghai
Dalian 24 High School, Dalian 116023, China.
Department of Neurosurgery, The Second Afiliated Hospital of Dalian Medical University, Dalian 116023, China.
Exp Cell Res. 2015 Dec 10;339(2):252-60. doi: 10.1016/j.yexcr.2015.09.015. Epub 2015 Sep 25.
miRNA-125 family, which is a highly conserved miRNA family throughout evolution, is consist of miRNA-125a-3p, miRNA-125a-5p, miRNA-125b-1 and miRNA-125b-2.The aberrant expression of miR-125 familyis tightly related to tumorigenesis and tumor development. The downstream targets of miRNA-125 include transcription factors like STAT3, cytokines like IL-6 and TGF-β, tumor suppressing protein p53, pro-apoptotic protein Bak1 and RNA binding protein HuR et al. Through regulating these downstream targets miR-125 family is involved in regulating tumorigenesis and tumor development. Nowadays, miR-125b have already became a putative and valuable biomarker for cancer diagnosis, treatment and prognosis. In this review, we mainly summarize the dual function of miRNA-125 family in suppression and promotion of cancer cells and further elaborate its regulatory mechanisms from four facets, proliferation, apoptosis, invasion or metastasis and immune response.
miRNA - 125家族是进化过程中高度保守的miRNA家族，由miRNA - 125a - 3p、miRNA - 125a - 5p、miRNA - 125b - 1和miRNA - 125b - 2组成。miR - 125家族的异常表达与肿瘤发生和肿瘤发展密切相关。miRNA - 125的下游靶点包括转录因子如STAT3、细胞因子如IL - 6和TGF -β、肿瘤抑制蛋白p53、促凋亡蛋白Bak1和RNA结合蛋白HuR等。通过调节这些下游靶点，miR - 125家族参与调节肿瘤发生和肿瘤发展。如今，miR - 125b已成为癌症诊断、治疗和预后的一种潜在且有价值的生物标志物。在本综述中，我们主要总结miRNA - 125家族在抑制和促进癌细胞方面的双重功能，并从增殖、凋亡、侵袭或转移以及免疫反应四个方面进一步阐述其调控机制。
