Calzavara-Pinton Pier Giacomo, Rossi Maria Teresa, Zanca Arianna, Arisi Mariachiara, Gonzalez Salvador, Venturini Marina
Department of Dermatology, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Photodermatol Photoimmunol Photomed. 2016 Jan;32(1):22-7. doi: 10.1111/phpp.12209. Epub 2015 Nov 6.
The effects on the inflammatory and tanning responses of sunlight/UVR of several oral antioxidants are still unknown.
Assess intensity, time course of the inflammatory, and tanning responses to increasing dosages of solar-simulated radiation (SSR) at baseline and after oral supplementation of an extract of Polypodium leucotomos (PLE).
Ten healthy subjects underwent phototesting with SSR with a visual and spectrophotometrical assessment of the responses with or without daily oral supplementation of two tablets containing 240 mg of PLE for a total of 15 days.
Polypodium leucotomos supplementation induced a significant increase of the minimal erythema dose (MED), a faster recovery of the inflammation following the delivery of super-erythemal doses, and no significant changes of the minimal melanogenic dose (MMD). Spectrophotometric assessment of the Δa* in test areas exposed to equally doses of SSR did not show differences.
Polypodium leucotomos supplementation increased the MED and induced a faster recovery of the inflammation and a stronger tanning response with no changes in the melanogenic threshold.
几种口服抗氧化剂对阳光/紫外线辐射的炎症反应和晒黑反应的影响尚不清楚。
评估在基线时以及口服白藓提取物（PLE）后，对递增剂量的模拟太阳辐射（SSR）的炎症反应和晒黑反应的强度、时间进程。
10名健康受试者接受SSR光测试，在有或没有每日口服两片含240mg PLE的片剂共15天的情况下，通过视觉和分光光度法评估反应。
补充白藓提取物导致最小红斑剂量（MED）显著增加，超红斑剂量照射后炎症恢复更快，最小致黑剂量（MMD）无显著变化。对暴露于同等剂量SSR的测试区域的Δa*进行分光光度评估未显示差异。
补充白藓提取物增加了MED，并导致炎症恢复更快以及晒黑反应更强，而致黑阈值没有变化。
