职业性接触麻醉气体是否会导致促炎细胞因子增加？
Does occupational exposure to anesthetic gases lead to increase of pro-inflammatory cytokines?
作者信息
Chaoul Maurício Martins, Braz José Reinaldo C, Lucio Lorena Mendes C, Golim Márjorie A, Braz Leandro Gobbo, Braz Mariana Gobbo
机构信息
Faculdade de Medicina de Botucatu, Departamento de Anestesiologia, UNESP - Univ Estadual Paulista, Distrito de Rubião Junior, s/n, Botucatu, SP, 18618-970, Brazil.
Faculdade de Medicina de Botucatu, Divisão de Hemocentro, UNESP - Univ Estadual Paulista, Distrito de Rubião Junior, s/n, Botucatu, SP, 18618-970, Brazil.
出版信息
Inflamm Res. 2015 Dec;64(12):939-42. doi: 10.1007/s00011-015-0881-2. Epub 2015 Sep 26.
INTRODUCTION
There is great concern about the possible harmful effects of exposure to volatile anesthetics. The current study aimed at evaluating, for the first time, the effects of occupational exposure to anesthetic gases on physicians who work in operating rooms, by determining several inflammatory cytokines.
MATERIALS AND METHODS
Plasma inflammatory cytokines (IL-1β, -6, -8, -10, -12, TNF-α) were investigated in 30 individuals who were allocated into two groups of 15: the exposed group, consisting of operating room medical personnel exposed to a mixture of anesthetic gases for 3 years, and a control group composed of medical personnel not exposed to anesthetic gases. The concentrations of volatile anesthetics were measured in the operating room by means of an infrared portable analyzer
RESULTS AND CONCLUSIONS
Our findings suggest an increase of the pro-inflammatory IL-8 (p<0.05) in medical personnel exposed to high concentrations of anesthetic gases, even for a relatively short period.
引言
人们非常关注接触挥发性麻醉剂可能产生的有害影响。本研究首次旨在通过测定几种炎性细胞因子，评估手术室工作的医生职业接触麻醉气体的影响。
材料与方法
对30名个体进行血浆炎性细胞因子（IL-1β、-6、-8、-10、-12、TNF-α）研究，将其分为两组，每组15人：暴露组，由接触麻醉气体混合物3年的手术室医务人员组成；对照组，由未接触麻醉气体的医务人员组成。通过红外便携式分析仪在手术室测量挥发性麻醉剂的浓度。
结果与结论
我们的研究结果表明，即使在相对较短的时间内，接触高浓度麻醉气体的医务人员中促炎细胞因子IL-8有所增加（p<0.05）。
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