Chan C, Bode L, Kim J
J Neonatal Perinatal Med. 2015;8(2):99-104. doi: 10.3233/NPM-15814055.
Galectin-3 binding protein (Gal3BP) is a glycoprotein isolated in colostrum that may be an immunologically active component with effects on the neonatal immune system. This compound has been found in the blood of term newborn infants, but has not been studied in preterm infants.
Compare umbilical cord plasma Gal3BP concentration between preterm and term infants.
Observational study of mother-infant pairs consented at UCSD Medical Center comparing umbilical cord plasma Gal3BP concentration in preterm and term infants. Umbilical cord plasma was collected at birth and stored at -80°C before Gal3BP analysis by ELISA. This study was powered to evaluate differences in preterm and term infant Gal3BP concentration. The secondary aim was to determine the effect of maternal and infant clinical factors on Gal3BP concentration.
A total of 64 preterm and 30 term umbilical cord plasma samples were analyzed. By univariate analysis, Gal3BP concentration was elevated in the setting of prematurity, maternal diabetes, antenatal steroid exposure, and increasing maternal parity (p < 0.05); and decreased in chorioamnionitis (p = 0.03). Using a multiple linear regression model prematurity, chorioamnionitis and maternal diabetes remained significant.
Umbilical cord plasma Gal3BP concentration is elevated in prematurity. This may reflect inflammatory states in infant and mother, but further study is warranted.
半乳糖凝集素-3结合蛋白（Gal3BP）是一种从初乳中分离出的糖蛋白，可能是一种对新生儿免疫系统有影响的免疫活性成分。已在足月儿的血液中发现这种化合物，但尚未在早产儿中进行研究。
比较早产儿和足月儿脐带血血浆中Gal3BP的浓度。
在加州大学圣地亚哥分校医学中心对母婴对进行观察性研究，比较早产儿和足月儿脐带血血浆中Gal3BP的浓度。出生时采集脐带血血浆，在通过酶联免疫吸附测定法（ELISA）分析Gal3BP之前，将其储存在-80°C。本研究旨在评估早产儿和足月儿Gal3BP浓度的差异。次要目的是确定母婴临床因素对Gal3BP浓度的影响。
共分析了64份早产儿和30份足月儿的脐带血血浆样本。单因素分析显示，在早产、母亲患糖尿病、产前接触类固醇以及母亲产次增加的情况下，Gal3BP浓度升高（p<0.05）；而在绒毛膜羊膜炎时Gal3BP浓度降低（p=0.03）。使用多元线性回归模型，早产、绒毛膜羊膜炎和母亲患糖尿病仍然具有显著意义。
早产时脐带血血浆Gal3BP浓度升高。这可能反映了婴儿和母亲的炎症状态，但仍需进一步研究。
