Simone Procopio, Alberto Migliore
Unit of Rheumatology "Ospedale S. Pietro FBF", Via Cassia 600, 00189, Rome, Italy.
Clin Drug Investig. 2015 Nov;35(11):689-92. doi: 10.1007/s40261-015-0339-x.
Intra-articular administration of hyaluronic acid is a valuable therapeutic tool for the management of patients with osteoarthritis. However, in recent years numerous formulations containing hyaluronic acid administrable by oral route have entered the market. Even if there are some data in the literature that have shown their effectiveness, systemic administration may expose a greater risk in certain situations. In fact, although hyaluronic acid is not considered a drug it is certain that it can interact with specific receptors and promote cell proliferation. This interaction may be potentially hazardous in cancer patients for which these oral formulations should be contraindicated.
关节腔内注射透明质酸是治疗骨关节炎患者的一种有价值的治疗手段。然而，近年来，许多可口服的含透明质酸制剂已进入市场。尽管文献中有一些数据表明了它们的有效性，但在某些情况下，全身给药可能会带来更大的风险。事实上，虽然透明质酸不被视为一种药物，但可以肯定的是，它能够与特定受体相互作用并促进细胞增殖。这种相互作用在癌症患者中可能具有潜在危险性，因此这些口服制剂对癌症患者应属禁忌。
