Laboratory of Computational Medicine, Biostatistics Unit, Universitat Autónoma de Barcelona, 08193 Barcelona, Spain.
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red: Enfermedades neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5 28031, Madrid, Spain.
Trends Biochem Sci. 2015 Oct;40(10):548-551. doi: 10.1016/j.tibs.2015.07.007.
G-Protein-coupled receptors (GPCRs) were classically described as monomers. We now appreciate that they also function as homo- and hetero-oligomers, for which structural information is lacking. Here, we use available 3D structures and biochemical considerations to present and evaluate experimentally testable structural models for GPCR oligomers and associated G proteins.
G 蛋白偶联受体 (GPCRs) 传统上被描述为单体。我们现在意识到，它们也作为同型和异型寡聚体发挥作用，但缺乏结构信息。在这里，我们利用现有的 3D 结构和生化考虑因素，提出并评估了可用于实验测试的 GPCR 寡聚体和相关 G 蛋白的结构模型。
