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功能性神经障碍:机制与治疗

Functional neurological disorders: mechanisms and treatment.

作者信息

Lehn Alexander, Gelauff Jeannette, Hoeritzauer Ingrid, Ludwig Lea, McWhirter Laura, Williams Stevie, Gardiner Paula, Carson Alan, Stone Jon

机构信息

Department of Neurology, Princess Alexandra Hospital, Brisbane, Australia.

School of Medicine, University of Queensland, Brisbane, Australia.

出版信息

J Neurol. 2016 Mar;263(3):611-20. doi: 10.1007/s00415-015-7893-2. Epub 2015 Sep 26.

DOI:10.1007/s00415-015-7893-2
PMID:26410744
Abstract

Functional neurological disorders are common problems in neurologic practice. In the past decade there has been an increasing interest in this group of disorders both from a clinical as well as research point of view. In this review, we highlight some of the most salient and exciting publications from recent years focusing especially on new findings illuminating mechanism and studies examining treatment.

摘要

功能性神经障碍是神经科临床实践中的常见问题。在过去十年中,从临床和研究角度来看,人们对这组疾病的兴趣与日俱增。在本综述中,我们重点介绍近年来一些最突出和令人兴奋的出版物,特别关注阐明机制的新发现以及研究治疗方法的研究。

相似文献

1
Functional neurological disorders: mechanisms and treatment.功能性神经障碍:机制与治疗
J Neurol. 2016 Mar;263(3):611-20. doi: 10.1007/s00415-015-7893-2. Epub 2015 Sep 26.
2
Functional neurologic disorders.功能性神经障碍。
Continuum (Minneap Minn). 2015 Jun;21(3 Behavioral Neurology and Neuropsychiatry):818-37. doi: 10.1212/01.CON.0000466669.02477.45.
3
Treatment for Patients With a Functional Neurological Disorder (Conversion Disorder): An Integrated Approach.功能性神经障碍(转换障碍)患者的治疗:一种综合方法。
Am J Psychiatry. 2018 Apr 1;175(4):307-314. doi: 10.1176/appi.ajp.2017.17040450.
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Occupational therapy for functional neurological disorders: a scoping review and agenda for research.功能性神经障碍的职业治疗:范围综述及研究议程。
CNS Spectr. 2018 Jun;23(3):205-212. doi: 10.1017/S1092852917000797. Epub 2017 Nov 27.
5
Somatization and conversion disorder.躯体化障碍和转换障碍。
Can J Psychiatry. 2004 Mar;49(3):172-8. doi: 10.1177/070674370404900304.
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Functional neurological disorders: the neurological assessment as treatment.功能性神经障碍:作为治疗手段的神经学评估。
Pract Neurol. 2016 Feb;16(1):7-17. doi: 10.1136/practneurol-2015-001241. Epub 2015 Dec 29.
7
[Functional neurological symptoms and the positive diagnostic process].[功能性神经症状与阳性诊断过程]
Ugeskr Laeger. 2018 Apr 23;180(17).
8
["Functional" disorders--from the viewpoint of the neurologist].["功能性"疾病——从神经科医生的视角来看]
Schweiz Med Wochenschr. 1993 Oct 23;123(42):1969-76.
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Functional neurological symptoms.功能性神经症状
J R Coll Physicians Edinb. 2011 Mar;41(1):38-41; quiz 42. doi: 10.4997/JRCPE.2011.110.
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Inpatient treatment for functional neurologic disorders.功能性神经障碍的住院治疗。
Handb Clin Neurol. 2016;139:631-641. doi: 10.1016/B978-0-12-801772-2.00051-5.

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ND-AMD: A Web-Based Database for Animal Models of Neurological Disease With Analysis Tools.ND-AMD:一个基于网络的神经疾病动物模型数据库及分析工具。
CNS Neurosci Ther. 2025 May;31(5):e70411. doi: 10.1111/cns.70411.
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Role of Fibroblast Growth Factors in Neurological Disorders: Insight into Therapeutic Approaches and Molecular Mechanisms.成纤维细胞生长因子在神经疾病中的作用:对治疗方法和分子机制的深入了解
Mol Neurobiol. 2025 Apr 26. doi: 10.1007/s12035-025-04962-x.
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A Critical Examination of the Clinical Diagnosis of Functional Tic-like Behaviors.

本文引用的文献

1
Rehabilitative therapies for chronic fatigue syndrome: a secondary mediation analysis of the PACE trial.慢性疲劳综合征的康复治疗:PACE试验的二次中介分析
Lancet Psychiatry. 2015 Feb;2(2):141-52. doi: 10.1016/S2215-0366(14)00069-8. Epub 2015 Jan 28.
2
Efficacy of brief interdisciplinary psychotherapeutic intervention for motor conversion disorder and nonepileptic attacks.短暂跨学科心理治疗对运动性转换障碍和非癔症性发作的疗效。
Gen Hosp Psychiatry. 2015 Sep-Oct;37(5):448-55. doi: 10.1016/j.genhosppsych.2015.05.007. Epub 2015 May 29.
3
Phenotype-specific diagnosis of functional (psychogenic) movement disorders.
功能型抽动样行为的临床诊断之批判性研究。
Mov Disord Clin Pract. 2024 Sep;11(9):1065-1071. doi: 10.1002/mdc3.14150. Epub 2024 Jun 28.
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Comprehensive Insights into Metastasis-Associated Spinal Cord Compression: Pathophysiology, Diagnosis, Treatment, and Prognosis: A State-of-the-Art Systematic Review.转移性脊髓压迫症的综合见解:病理生理学、诊断、治疗及预后:一项最新的系统评价
J Clin Med. 2024 Jun 19;13(12):3590. doi: 10.3390/jcm13123590.
5
Increased Cyclic Adenosine Monophosphate Responsive Element is Closely Associated with the Pathogenesis of Drug-resistant Epilepsy.环磷酸腺苷反应元件的增加与耐药性癫痫的发病机制密切相关。
Curr Neurovasc Res. 2024;21(1):54-63. doi: 10.2174/0115672026290996240307072539.
6
Costs of adult functional neurological disorders at a tertiary hospital in central South Africa.南非中部一家三级医院成人功能性神经障碍的费用。
S Afr J Psychiatr. 2023 Jun 20;29:2010. doi: 10.4102/sajpsychiatry.v29i0.2010. eCollection 2023.
7
Physical Rehabilitation of Motor Functional Neurological Disorders: A Narrative Review.运动功能神经障碍的物理康复:叙述性综述。
Int J Environ Res Public Health. 2023 May 11;20(10):5793. doi: 10.3390/ijerph20105793.
8
The neurobiology of functional neurological disorders characterised by impaired awareness.以意识障碍为特征的功能性神经障碍的神经生物学
Front Psychiatry. 2023 Mar 16;14:1122865. doi: 10.3389/fpsyt.2023.1122865. eCollection 2023.
9
Diagnostic pitfalls in functional neurological disorders.功能性神经疾病的诊断陷阱。
Arq Neuropsiquiatr. 2022 May;80(5 Suppl 1):324-327. doi: 10.1590/0004-282X-ANP-2022-S120.
10
Olfactory Drug Aerosol Delivery with Acoustic Radiation.基于声辐射的嗅觉药物气雾剂递送
Biomedicines. 2022 Jun 8;10(6):1347. doi: 10.3390/biomedicines10061347.
功能性(心理性)运动障碍的表型特异性诊断
Curr Neurol Neurosci Rep. 2015 Jun;15(6):32. doi: 10.1007/s11910-015-0556-y.
4
Fowler's syndrome of urinary retention: A retrospective study of co-morbidity.福勒氏尿潴留综合征:合并症的回顾性研究
Neurourol Urodyn. 2016 Jun;35(5):601-3. doi: 10.1002/nau.22758. Epub 2015 Apr 10.
5
Emotion-motion interactions in conversion disorder: an FMRI study.转换障碍中的情绪与运动交互作用:一项功能磁共振成像研究。
PLoS One. 2015 Apr 10;10(4):e0123273. doi: 10.1371/journal.pone.0123273. eCollection 2015.
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Can repetitive transcranial magnetic stimulation increase muscle strength in functional neurological paresis? A proof-of-principle study.
Eur J Neurol. 2015 May;22(5):866-73. doi: 10.1111/ene.12684. Epub 2015 Feb 24.
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'Scan-negative' cauda equina syndrome: Evidence of functional disorder from a prospective case series.
Br J Neurosurg. 2015 Apr;29(2):178-80. doi: 10.3109/02688697.2014.1003032. Epub 2015 Feb 3.
8
Head accelerometry may be useful as a test of psychogenic head tremor.头部加速度测量法可能作为精神性头部震颤的一项检测手段很有用。
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J Neurol. 2015 Mar;262(3):674-81. doi: 10.1007/s00415-014-7631-1. Epub 2015 Jan 4.