Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
Psychiatry Res. 2015 Dec 15;230(2):394-9. doi: 10.1016/j.psychres.2015.09.026. Epub 2015 Sep 18.
Obsessive-compulsive disorder (OCD) is one of the most common mental health disorders, characterized by obsessive thoughts and/or compulsive behaviors, which may involve specific disorders in cognition and/or information processing. Event-related potentials (ERPs) are commonly used as physiological measures of cognitive function as they are easily measured and noninvasive. In the present study, 20 drug-naïve pediatric patients with OCD were compared with 20 healthy control participants who were age- and sex-matched to perform the ERP. Based on the guidelines for evoked potential measurement, the P300 and mismatch negativity (MMN) were obtained by auditory odd-ball tasks. We found that the amplitudes of the P300 components in the Fz, Cz, Pz, C3, and C4 regions were significantly smaller in the OCD group compared with the control group. There were no between-group differences in P300 latency, MMN amplitude, or MMN latency. Moreover, we found significant correlations between scores on the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) and P300 amplitudes at Cz, Pz, and C3. The present study is the first to report smaller P300s and the associations between P300 abnormalities and CY-BOCS scores.
强迫症（OCD）是最常见的心理健康障碍之一，其特征为强迫性思维和/或强迫性行为，可能涉及认知和/或信息处理方面的特定障碍。事件相关电位（ERP）通常被用作认知功能的生理测量指标，因为它们易于测量且无创伤。在本研究中，我们将 20 名未经药物治疗的儿科 OCD 患者与 20 名年龄和性别匹配的健康对照组参与者进行比较，以进行 ERP 检查。根据诱发电位测量指南，通过听觉Odd-ball 任务获得 P300 和失匹配负波（MMN）。我们发现 OCD 组 Fz、Cz、Pz、C3 和 C4 区域的 P300 成分的振幅明显小于对照组。P300 潜伏期、MMN 振幅或 MMN 潜伏期在两组之间没有差异。此外，我们发现儿童耶鲁-布朗强迫症量表（CY-BOCS）评分与 Cz、Pz 和 C3 的 P300 振幅之间存在显著相关性。本研究首次报道了 P300 振幅较小以及 P300 异常与 CY-BOCS 评分之间的相关性。
