Chaix Amandine, Zarrinpar Amir, Miu Phuong, Panda Satchidananda
Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Division of Gastroenterology, University of California, San Diego, La Jolla, CA 92093, USA.
Cell Metab. 2014 Dec 2;20(6):991-1005. doi: 10.1016/j.cmet.2014.11.001.
Because current therapeutics for obesity are limited and only offer modest improvements, novel interventions are needed. Preventing obesity with time-restricted feeding (TRF; 8-9 hr food access in the active phase) is promising, yet its therapeutic applicability against preexisting obesity, diverse dietary conditions, and less stringent eating patterns is unknown. Here we tested TRF in mice under diverse nutritional challenges. We show that TRF attenuated metabolic diseases arising from a variety of obesogenic diets, and that benefits were proportional to the fasting duration. Furthermore, protective effects were maintained even when TRF was temporarily interrupted by ad libitum access to food during weekends, a regimen particularly relevant to human lifestyle. Finally, TRF stabilized and reversed the progression of metabolic diseases in mice with preexisting obesity and type II diabetes. We establish clinically relevant parameters of TRF for preventing and treating obesity and metabolic disorders, including type II diabetes, hepatic steatosis, and hypercholesterolemia.
由于目前用于治疗肥胖症的方法有限，且效果改善程度不大，因此需要新的干预措施。限时进食（TRF；在活跃期有8 - 9小时的进食时间）有望预防肥胖症，但其对已存在的肥胖症、不同饮食条件以及不太严格的饮食模式的治疗适用性尚不清楚。在此，我们在不同营养挑战下对小鼠进行了限时进食测试。我们发现，限时进食减轻了由各种致肥胖饮食引起的代谢疾病，且益处与禁食持续时间成正比。此外，即使在周末随意进食暂时中断限时进食的情况下，保护作用依然存在，这种饮食方案与人类生活方式尤为相关。最后，限时进食稳定并逆转了已患有肥胖症和II型糖尿病的小鼠体内代谢疾病的进展。我们确定了限时进食在预防和治疗肥胖症及代谢紊乱（包括II型糖尿病、肝脂肪变性和高胆固醇血症）方面与临床相关的参数。
