GPR43- 一种连接代谢性和炎症性疾病的典型代谢物传感器。
GPR43 - A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory Diseases.
机构信息
Department of Immunology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
Department of Immunology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Wellington Road, Clayton, Victoria 3800, Australia; Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA.
出版信息
Trends Endocrinol Metab. 2015 Oct;26(10):511-512. doi: 10.1016/j.tem.2015.07.009.
Short-chain fatty acids (SCFAs) are released upon fermentation of dietary fiber by gut bacteria. G protein-coupled receptor 43 (GPR43), a key receptor for SCFAs, is expressed on cell types important for immunity and metabolism. GPR43 modulates both inflammatory and metabolic processes, and is crucial for understanding the pathogenesis of 'Western lifestyle' diseases.
短链脂肪酸（SCFAs）是肠道细菌发酵膳食纤维后释放的物质。G 蛋白偶联受体 43（GPR43）是 SCFAs 的关键受体，表达于对免疫和代谢很重要的细胞类型上。GPR43 调节炎症和代谢过程，对于理解“西方生活方式”疾病的发病机制至关重要。
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