Geng Di, Yi Li-Tao, Shi Yao, Min Zhi-Da
College of Chemical Engineering, Huaqiao University, Xiamen 361021, China.
College of Chemical Engineering, Huaqiao University, Xiamen 361021, China.
Chin J Nat Med. 2015 Sep;13(9):704-6. doi: 10.1016/S1875-5364(15)30069-8.
The present study was designed to isolate and evaluate the antibacterial activity of the compounds from the whole plant of Euphorbia helioscopia L.. Various chromatographic techniques were used to isolate and purify the compound. The structure of the compound was elucidated on basis of spectral data ((1)H NMR, (13)C NMR, (1)H-(1)H COSY, HSQC, HMBC, NOESY, IR, and HR-ESI-MS). A new jatrophone-type diterpenoid (14α,15β-diacetoxy-3β-benzoyloxy-7β-nicotinoyloxy-9-oxo-jatropha-5E,11E-diene), named euphoheliosnoid E (1), was isolated from the whole plant of E. helioscopia L. Compound 1 showed significant anti-microbial activity against oral pathogens.
本研究旨在从泽漆全草中分离并评估化合物的抗菌活性。采用多种色谱技术分离和纯化该化合物。基于光谱数据（¹H NMR、¹³C NMR、¹H-¹H COSY、HSQC、HMBC、NOESY、IR和HR-ESI-MS）阐明该化合物的结构。从泽漆全草中分离出一种新的麻风树型二萜（14α,15β-二乙酰氧基-3β-苯甲酰氧基-7β-烟酰氧基-9-氧代-麻风树-5E,11E-二烯），命名为泽漆二萜E（1）。化合物1对口腔病原体显示出显著的抗菌活性。
