Iskandar Benni, Lukman Anita, Syaputra Sandika, Al-Abrori Ucy N H, Surboyo Meircurius D C, Lee Ching-Kuo
School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Department of Pharmaceutical Technology, Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru, Riau, Indonesia.
J Taibah Univ Med Sci. 2021 Sep 17;17(2):271-282. doi: 10.1016/j.jtumed.2021.08.009. eCollection 2022 Apr.
Mouthwash is a liquid solution used to improve oral health and breath freshness as well as reduce oral bacteria. This study aims to formulate a ethanol extract for mouthwash, evaluate the physical properties, and determine its anti-bacterial effects against .
Each mouthwash formula was created by utilising a solubilisation technique. Three mouthwash formulas were created from different concentrations of ethanol extract (0.5%, 1%, and 2%), and referred to as F1, F2, and F3. The organoleptic properties, pH levels, specific gravity, viscosity, flow properties, stability, irritation level, contact time, and anti-bacterial effects were evaluated for each concentration.
The resulting formulas featured a distinctive smell of and had a sweet and spicy taste. These characteristics remained unaffected during storage. The acidity levels ranged from 4.59 to 6.0, the weight masses ranged from 0.9693 to 1.0710 g/ml, and the viscosity ranged from 1.50 to 3.00 cP. F3 concentration was non-irritating with mucus production at 11.325%, had lower contact time with a neutralisation of 57.14% of colonies in 30 seconds, and showed stable anti-bacterial control against ( = 0.000) within the first week of use.
The study results offer the first proof of used for improving human health. The formulation features the ideal physical and stability characteristics of mouthwash, and possesses anti-bacterial properties that can potentially combat . Clinical use of the formulated mouthwash must be explored in future research.
漱口水是一种用于改善口腔健康、保持口气清新以及减少口腔细菌的液体溶液。本研究旨在配制一种用于漱口水的乙醇提取物，评估其物理性质，并确定其对……的抗菌效果。
每种漱口水配方均采用增溶技术制备。由不同浓度的乙醇提取物（0.5%、1%和2%）制备了三种漱口水配方，分别称为F1、F2和F3。对每种浓度的感官特性、pH值、比重、粘度、流动性、稳定性、刺激程度、接触时间和抗菌效果进行了评估。
所得配方具有……的独特气味，味道甜辣。这些特性在储存过程中未受影响。酸度水平在4.59至6.0之间，重量质量在0.9693至1.0710 g/ml之间，粘度在1.50至3.00 cP之间。F3浓度无刺激性，粘液产生率为11.325%，接触时间较短，在30秒内可中和57.14%的……菌落，并在使用的第一周内对……显示出稳定的抗菌控制（P = 0.000）。
研究结果首次证明了……可用于改善人类健康。该配方具有漱口水理想的物理和稳定性特征，并具有潜在对抗……的抗菌特性。未来的研究必须探索所配制漱口水的临床应用。
