从胡桃楸中鉴定新的萘醌并评估其抗癌活性。 （注：原文中“Identfication”拼写错误，应为“Identification”；“evalution”拼写错误，应为“evaluation”）
Identfication of new naphthalenones from Juglans mandshurica and evalution of their anticancer activities.
作者信息
Guo Li-Na, Zhang Rui, Guo Xue-Ying, Cui Tao, Dong Wei, Huo Jin-Hai, Wang Wei-Ming
机构信息
School of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China.
Institute of Traditional Chinese Medicine, Heilongjiang Traditional Chinese Medicine Academy of Sciences, Harbin 110016, China.
出版信息
Chin J Nat Med. 2015 Sep;13(9):707-10. doi: 10.1016/S1875-5364(15)30070-4.
Two new naphthalenone compounds were isolated from green walnut husks of Juglans mandshurica and their structures were identified as 4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (1), 4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (2). Compounds 1 and 2 were named as Juglanstetralone A (1) and Juglanstetralone B (2). Compound 1 showed more significant anti-tumor activity than 2 against gastric cancer BGC-823 cells, wih the IC50 of 125.89 (g(mL(-1).
从胡桃楸的青核桃壳中分离出两种新的萘醌化合物，其结构被鉴定为4-丁氧基丁氧基-5,8-二羟基-3,4-二氢-2H-萘-1-酮（1）、4-乙氧基乙氧基-5,8-二羟基-3,4-二氢-2H-萘-1-酮（2）。化合物1和2分别被命名为胡桃四酮A（1）和胡桃四酮B（2）。化合物1对胃癌BGC-823细胞的抗肿瘤活性比化合物2更强，其IC50为125.89 μg/mL。
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