从胡桃楸青胡桃壳中分离出的两种新的细胞毒性糖苷。
Two new cytotoxic glycosides isolated from the green walnut husks of Juglans mandshurica Maxim.
作者信息
Zhou Yuan-Yuan, Liu Quan-Yu, Yang Bing-You, Jiang Yan-Qiu, Liu Yu-Xin, Wang Ying, Guo Shuang, Kuang Haixue
机构信息
a College of Pharmacy , Heilongjiang University of Chinese Medicine , Harbin , P.R. China.
b Quality Testing Branch , Veterinary Drug and Feed Supervision Institute of Heilongjiang Province , Harbin , P.R. China.
出版信息
Nat Prod Res. 2017 Jun;31(11):1237-1244. doi: 10.1080/14786419.2016.1233412. Epub 2016 Sep 26.
Two new glycosides including an alcohol glycoside and a phenolic glycoside: hexyl-1-O-α-d-arabinofuranosyl-(1 → 6)-β-d-glucopyranoside (1), 4-hydroxypropiophenone-4-O-β-d-glucopyranosyl(1 → 6)-β-d-glucopyranoside(2), along with six known naphthalenyl glucosides (3-8) were isolated from green walnut husks of Juglans mandshurica, and their structures were elucidated on the basis of spectroscopic studies. All compounds were evaluated for their inhibitory effects on tumour cells (BGC-823, HepG-2, MCF-7). The results showed that new compounds 1 and 2 had superior inhibitory activity in comparison with other naphthalenyl glucosides.
从胡桃楸的青核桃壳中分离出两种新的糖苷，包括一种醇糖苷和一种酚糖苷：己基-1-O-α-D-阿拉伯呋喃糖基-(1→6)-β-D-吡喃葡萄糖苷(1)、4-羟基苯丙酮-4-O-β-D-吡喃葡萄糖基(1→6)-β-D-吡喃葡萄糖苷(2)，以及六种已知的萘基葡萄糖苷(3-8)，并通过光谱研究阐明了它们的结构。对所有化合物进行了对肿瘤细胞（BGC-823、HepG-2、MCF-7）的抑制作用评估。结果表明，新化合物1和2与其他萘基葡萄糖苷相比具有更强的抑制活性。
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