对一组撒哈拉以南非洲绝经后妇女心血管事件10年风险的评估。

Assessment of the 10-year risk of cardiovascular events among a group of Sub-Saharan African post-menopausal women.

作者信息

Ama Moor Vicky Jocelyne, Nansseu Jobert Richie N, Nouaga Murielle Elsa D, Noubiap Jean Jacques N, Nguetsa Guylaine D, Tchanana Gladys, Ketcha Arthur, Fokom-Domgue Joël

机构信息

Department of Public Heanth, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

出版信息

Cardiol J. 2016;23(2):123-31. doi: 10.5603/CJ.a2015.0056. Epub 2015 Sep 28.

DOI:10.5603/CJ.a2015.0056

PMID:26412602

Abstract

BACKGROUND

Post-menopausal women may be at particular risk of developing cardiovascu-lar disease due to metabolic changes occurring at menopause. The present study aimed to assess the 10-year cardiovascular risk (CVR) among a group of post-menopausal women and to deter-mine associated factors.

METHODS

This was a cross-sectional study conducted among post-menopausal women in Yaoundé, Cameroon. CVR was calculated using the Framingham risk score.

RESULTS

We enrolled 108 women, their ages ranging from 45 to 80 years, with a mean of 56.4 ± ± 6.9 years. CVR ranged between 1.2% and greater than 30% with a mean of 13.4 ± 8.7%. Forty-three (39.8%) participants had a low CVR (< 10%), 39 (36.1%) women had a moderate CVR (10-20%), and 21 (24.1%) women had a high CVR (> 20%). Low-density lipoproteins cholesterol (LDL-C; b = 3.27, p = 0.004), fasting plasma glucose (b = 5.40, p = 0.015), and diastolic blood pressure (DBP; b = 3.49, p < 0.0001) were independently associated with CVR. Women not married (i.e. single, divorced or widowed) (adjusted odds ratio [aOR] 4.66, p = 0.002), those with high titers of LDL-C (≥ 1.6 g/L; aOR 5.07, p = 0.001), and those with elevated DBP (≥ 90 mm Hg; aOR 8.10, p < 0.0001) presented an increased likelihood to be at an advanced level of CVR.

CONCLUSIONS

A significant number of post-menopausal women are at considerable risk of cardiovascular events in our setting. Therefore, they should be educated to adopt healthy life-styles for substantial reduction in their CVR.

摘要

背景

绝经后女性由于绝经时发生的代谢变化，可能特别容易患心血管疾病。本研究旨在评估一组绝经后女性的10年心血管风险（CVR）并确定相关因素。

方法

这是一项在喀麦隆雅温得的绝经后女性中进行的横断面研究。使用弗明汉风险评分计算CVR。

结果

我们招募了108名女性，年龄在45至80岁之间，平均年龄为56.4±6.9岁。CVR在1.2%至超过30%之间，平均为13.4±8.7%。43名（39.8%）参与者的CVR较低（<10%），39名（36.1%）女性的CVR中等（10-20%），21名（24.1%）女性的CVR较高（>20%）。低密度脂蛋白胆固醇（LDL-C；b = 3.27，p = 0.004）、空腹血糖（b = 5.40，p = 0.015）和舒张压（DBP；b = 3.49，p < 0.0001）与CVR独立相关。未婚女性（即单身、离婚或丧偶）（调整优势比[aOR]为4.66，p = 0.002）、LDL-C水平高（≥1.6 g/L；aOR为5.07，p = 0.001）以及DBP升高（≥90 mmHg；aOR为8.10，p < 0.0001）的女性处于CVR较高水平的可能性增加。