Lee Hyungbin, Jung Young-Hyo, Kwon Yu-Jin, Park Byoungjin
Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea.
Korean J Fam Med. 2017 Nov;38(6):333-337. doi: 10.4082/kjfm.2017.38.6.333. Epub 2017 Nov 14.
Uric acid has been reported to function both as an oxidant or antioxidant depending on the context. A previous study in the Korean population reported a positive linear association between serum uric acid level and arterial stiffness in men, but little is known about how serum uric acid level is related to the risk of increased arterial stiffness in Korean postmenopausal women.
We performed a cross-sectional study of 293 subjects who participated in a health examination program run by the health promotion center of Gangnam Severance Hospital between October 2007 and July 2010. High brachial-ankle pulse wave velocity was defined as a brachial-ankle pulse wave velocity of more than 1,450 cm/s. The odds ratios (ORs) for high brachial-ankle pulse wave velocity were calculated using multivariate logistic regression analysis across uric acid quartiles after adjusting for other indicators of cardiovascular risk.
The 293 postmenopausal women were divided into quartiles according to uric acid level. The mean brachial-ankle pulse wave velocity values of each quartile were as follows: Q1, 1,474 cm/s; Q2, 1,375 cm/s; Q3, 1,422 cm/s; Q4, 1,528 cm/s. The second quartile was designated as the control group based on mean brachial-ankle pulse wave velocity value. Multivariate adjusted ORs (95% confidence intervals) for brachial-ankle pulse wave velocity across the uric acid quartiles were 2.642 (Q1, 1.095-6.3373), 1.00, 4.305 (Q3, 1.798-10.307), and 4.375 (Q4, 1.923-9.949), after adjusting for confounding variables.
Serum uric acid level has a J-shaped association with arterial stiffness in Korean postmenopausal women.
据报道，尿酸根据具体情况既可以作为氧化剂，也可以作为抗氧化剂发挥作用。此前一项针对韩国人群的研究报告称，男性血清尿酸水平与动脉僵硬度呈正线性关联，但关于韩国绝经后女性血清尿酸水平与动脉僵硬度增加风险之间的关系，人们知之甚少。
我们对293名受试者进行了一项横断面研究，这些受试者于2007年10月至2010年7月参加了江南Severance医院健康促进中心开展的一项健康检查项目。高臂踝脉搏波速度定义为臂踝脉搏波速度超过145厘米/秒。在调整了心血管风险的其他指标后，使用多变量逻辑回归分析计算尿酸四分位数组中高臂踝脉搏波速度的比值比（OR）。
293名绝经后女性根据尿酸水平分为四分位数组。各四分位数组的平均臂踝脉搏波速度值如下：Q1为1474厘米/秒；Q2为1375厘米/秒；Q3为1422厘米/秒；Q4为1528厘米/秒。根据平均臂踝脉搏波速度值，将第二四分位数组指定为对照组。在调整混杂变量后，尿酸四分位数组中臂踝脉搏波速度的多变量调整OR（95%置信区间）分别为2.642（Q1，1.095 - 6.3373）、1.00、4.305（Q3，1.798 - 10.307）和4.375（Q4，1.923 - 9.949）。
韩国绝经后女性血清尿酸水平与动脉僵硬度呈J形关联。
