Masuda Manami, Era Mariko, Kawahara Takayoshi, Kanyama Takahide, Morita Hiroshi
Graduate School of Environmental Engineering, University of Kitakyushu.
Biocontrol Sci. 2015;20(3):209-13. doi: 10.4265/bio.20.209.
Fatty acid salts are a type of surfactant known to have potent antibacterial activity. We therefore examined the antibacterial activities of fatty acid salts against Streptococcus mutans. Potassium caprylate (C10K), potassium laurate (C12K), potassium myristate (C14K), potassium oleate （C18:1K), potassium linoleate (C18:2K), and potassium linolenate (C18:3K), used at a concentration of 175 mM, resulted in a 7 log-unit reduction of S. mutans after a 10-min incubation. The minimum inhibitory concentration (MIC) of C18:2K and C18:3K was 5.5 mM. C12K also demonstrated high antibacterial activity (MIC of 21.9 mM). These results indicate that C12K, C18:2K, and C18:3K have high antibacterial activity against S. mutans, and possess great potential as antibacterial agents.
脂肪酸盐是一类已知具有强效抗菌活性的表面活性剂。因此，我们检测了脂肪酸盐对变形链球菌的抗菌活性。辛酸钾（C10K）、月桂酸钾（C12K）、肉豆蔻酸钾（C14K）、油酸钾（C18:1K）、亚油酸钾（C18:2K）和亚麻酸酸钾（C18:3K），以175 mM的浓度使用，在孵育10分钟后使变形链球菌减少了7个对数单位。C18:2K和C18:3K的最低抑菌浓度（MIC）为5.5 mM。C12K也表现出高抗菌活性（MIC为21.9 mM）。这些结果表明，C12K、C18:2K和C18:3K对变形链球菌具有高抗菌活性，并且作为抗菌剂具有巨大潜力。
